腹腔镜十二指肠溃疡穿孔修补术对患者创伤应激及胃黏膜VEGF、bFGF表达的影响研究OA
Study on the Influence of Laparoscopic Repair of Duodenal Ulcer Perforation for Traumatic Stress and Gastric Mucosa VEGF,bFGF of Patients
目的:探究腹腔镜十二指肠溃疡穿孔修补术对患者创伤应激及胃黏膜血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)表达的影响.方法:选取 2022 年 1 月—2024 年 1 月仁怀市人民医院手术治疗的 90 例十二指肠溃疡穿孔患者作为研究对象.依照随机数表法分为对照组(开腹十二指肠溃疡穿孔修补术组,n=45)与观察组(腹腔镜十二指肠溃疡穿孔修补术组,n=45).比较两组手术指标(手术时间、术中出血量、术后体温及并发症发生率)、胃肠功能恢复时间(肠鸣音、排气及排便时间)、手术前后的创伤应激[白细胞介素 1β(IL-1β)、瘦素(Leptin)及肿瘤坏死因子(TNF-α)]及胃黏膜 VEGF、bFGF 表达.结果:对照组与观察组的手术时间比较,差异无统计学意义(P>0.05);观察组的术中出血量少于对照组,术后体温低于对照组,并发症发生率低于对照组,胃肠功能恢复时间短于对照组,术后 3 d 及 5 d 观察组的创伤应激水平低于对照组,术后 4 周两组的胃黏膜VEGF及 bFGF表达高于组内术前,上述差异均有统计学意义(P<0.05).结论:腹腔镜十二指肠溃疡穿孔修补术对患者术后的病灶修复与开腹手术无明显差异,但对创伤反应程度的控制效果相对较好.
Objective:To investigate the influence of laparoscopic repair of duodenal ulcer perforation for traumatic stress and gastric mucosa VEGF,bFGF of patients.Method:A total of 90 patients with duodenal ulcer perforation who were admitted to Renhuai People's Hospital from January 2022 to January 2024 were selected as the research subjects.They were divided into the control group(open repair of duodenal ulcer perforation group,n=45)and the observation group(laparoscopic repair of duodenal ulcer perforation group,n=45)according to the random number table method.The operation indexes(operation time,intraoperative blood loss,postoperative body temperature and complication rates),recovery time of gastrointestinal function(bowel sound,exhaust and defecation time),traumatic stress[Interleukin(IL-1β),Leptin,Tumor necrosis factor-α(TNF-α)]and gastric mucosa VEGF,bFGF before and after the operation of two groups were compared.Result:There was no statistically significant difference in the operation time between the two group(P>0.05).The intraoperative blood loss of observation group was significantly less than that of control group,the postoperative body temperature of observation group was significantly lower than that of control group,the complication rate of obsenvation group was significantly lower than that of control group,the recovery time of gastrointestinal function were significantly shorter than those of control group,the traumatic stress of observation group at 3 and 5 day after the operation were significantly lower than those of control group,the gastric mucosa VEGF,bFGF expression levels of two groups at 4 week after the operation were significantly higher than those within group before the operation,the differences were all statistically significant(P<0.05).Conclusion:The difference of laparoscopic repair of duodenal ulcer perforation for lesion tissue repair is not significant to that of open operation,but its influence for degree of trauma response is relatively better.
黄海
仁怀市人民医院 贵州 仁怀 564500
腹腔镜手术开腹手术十二指肠溃疡穿孔修补术创伤应激胃黏膜血管内皮生长因子碱性成纤维细胞生长因子
Laparoscopic operationOpen operationRepair of duodenal ulcer perforationTraumatic stressGastric mucosaVascular endothelial growth factorBasic fibroblast growth factor
《中外医学研究》 2026 (12)
37-40,4
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