CA153、CA125、CA19-9、CA72-4水平与非小细胞肺癌术后患者预后的关系研究OA

Objective:To study the relationship between the levels of carbohydrate antigen 153(CA153),carbohydrate antigen 125(CA125),carbohydrate antigen 19-9(CA19-9),and carbohydrate antigen 72-4(CA72-4)and the prognosis of postoperative patients with non-small cell lung cancer(NSCLC).Method:A retrospective analysis was conducted on the clinical data of 278 patients who underwent radical resection of NSCLC in Gaochun Hospital of Traditional Chinese Medicine,Nanjing from January 2019 to April 2023.According to the follow-up results at 2 years after the operation,they were divided into the good prognosis group(n=115)and the poor prognosis group(n=163).The clinical data,CA153,CA125,CA19-9 and CA72-4 levels of patients with different prognostic conditions were compared,and the role of CA153,CA125,CA19-9 and CA72-4 levels in the prognosis assessment of patients were analyzed.Result:The age,the ratio of patients with a smoking history,the ratio of patients with lymph node metastasis,the ratio of patients at stage Ⅲ and Ⅳ of the tumor-lymph node metastasis staging system(TNM staging),and the levels of CA153,CA125,CA19-9,and CA72-4 in the poor prognosis group were significantly higher than those in the good prognosis group,and all the differences were statistically significant(P<0.05).Correlation analysis showed that there was a low to moderate positive correlation among the markers,and the VIF was all<2,with no severe collinearity.Logistic analysis showed that lymph node metastasis,TNM stage,CA153,CA125,CA19-9,and CA72-4 levels were all independent risk factors for poor prognosis(P<0.05).The ROC curve indicated that the combined AUC of CA153,CA125,CA19-9,and CA72-4 levels for predicting prognosis reached 0.897,which was superior to that of a single marker.After combining lymph node metastasis and TNM staging,the AUC further increased to 0.909.Based on the Youden Index,the optimal cut-off values of this center were determined to be 31.52 U/mL,61.38 U/mL,49.75 U/mL,and 41.63 U/mL respectively.Conclusion:Elevated CA153,CA125,CA19-9,and CA72-4 are independent predictors of poor prognosis after NSCLC surgery.Combined detection can significantly enhance the efficacy of prognosis assessment.This study verified the predictive value of the above markers in a localized single-center population and determined the optimal cut-off value of this center.It provides regional evidence-based basis for the postoperative management of NSCLC in this region.