基于阴道微生态探讨老年阴道炎复发风险因素OA
Exploring the Risk Factors for Recurrence of Bacterial Vaginitis in Elderly Women Based on Vaginal Microecology
目的:基于阴道微生态探讨老年阴道炎复发风险因素,为临床降低老年性阴道炎复发率提供依据.方法:回顾性选取2025 年 1 月—6 月齐齐哈尔医学院附属第一医院收治的 80 例老年阴道炎患者为研究对象,在患者治愈后第 1 个月采集阴道分泌物样本,根据其复发情况,将患者分为复发组(38 例)和非复发组(42 例).比较两组一般资料,采用多因素 logistic 回归分析老年阴道炎患者复发的影响因素.结果:两组微生态菌群密集度,菌群多样性,乳酸杆菌分级,pH,T 淋巴细胞,B 淋巴细胞,自然杀伤(NK)细胞,Nugent 评分,需氧菌性阴道炎(AV)评分比较,差异均有统计学意义(P<0.05);两组年龄、体重指数、类型、病史比较,差异均无统计学意义(P>0.05).老年阴道炎患者复发作为因变量,将单因素分析差异有统计学意义的指标作为自变量,进行多因素 logistic 回归分析,结果显示,微生态菌群密集度非Ⅱ～Ⅲ级(OR=1.084)、菌群多样性非Ⅱ～Ⅲ级(OR=1.085)、乳酸杆菌分级非Ⅰ～Ⅱa 级(OR=1.093)、pH>4.5(OR=1.092)、低CD4+(OR=1.082)、低CD8+(OR=1.081)、Nugent 评分≥4 分(OR=1.090)、AV 评分≥4 分(OR=1.088)是老年阴道炎患者复发的影响因素(P<0.05).结论:微生态菌群密集度非Ⅱ～Ⅲ级、菌群多样性非Ⅱ～Ⅲ级、乳酸杆菌分级非Ⅰ～Ⅱa 级、pH>4.5、低 CD4+、低 CD8+、Nugent 评分≥4 分、AV 评分≥4 分是老年阴道炎患者复发的影响因素,临床可借助以上指标预测老年阴道炎患者复发,提供患者预后.
Objective:To explore the risk factors for the recurrence of senile vaginitis based on vaginal microecology,and to provide a basis for reducing the recurrence rate of senile vaginitis in clinical practice.Method:A retrospective selection was made of 80 elderly patients with vaginitis admitted to the First Affiliated Hospital of Qiqihar Medical University from January 2025 to June 2025 as the research subjects.Vaginal secretion samples were collected in the first month after the patients were cured.According to the recurrence situation,the patients were divided into the recurrence group(38 cases)and the non-recurrence group(42 cases).The general data of the two groups were compared,and multivariate logistic regression analysis was used to analyze the influencing factors of recurrence in elderly patients with vaginitis.Result:There were statistically significant differences in the density of microecological flora,flora diversity,Lactobacillus classification,pH value,T lymphocytes,B lymphocytes,natural killer(NK)cells,Nugent score,and Aerobic Vaginitis(AV)score between the two groups(P<0.05).There were no statistically significant differences in age,body mass index,type and medical history between the two groups(P>0.05).The recurrence of elderly patients with vaginitis was taken as the dependent variable,and the indicators with statistical significance in the univariate analysis were taken as independent variables for multivariate logistic regression analysis.The results showed that Microecological flora density not at gradeⅡ～Ⅲ(OR=1.084),flora diversity not at grade Ⅱ～Ⅲ(OR=1.085),Lactobacillus grade not at grade Ⅰ～Ⅱa(OR=1.093),pH>4.5(OR=1.092),low CD4+(OR=1.082),low CD8+(OR=1.081),Nugent score≥4 points(OR=1.090)and AV score≥4 points(OR=1.088)are the influencing factors for recurrence in elderly patients with vaginitis(P<0.05).Conclusion:The factors influencing the recurrence of elderly patients with vaginitis include non-grade Ⅱ～Ⅲ microecological flora density,non-grade Ⅱ～Ⅲ flora diversity,non-grade Ⅰ～Ⅱa Lactobacillus classification,pH>4.5,low CD4+,low CD8+,Nugent score≥4 points,and AV score≥4 points.Clinically,the above indicators can be used to predict the recurrence of elderly patients with vaginitis and provide prognosis for the patients.
姜頔;栾磊;宋越;刘默;闫小景;杨松
齐齐哈尔医学院附属第一医院 黑龙江 齐齐哈尔 161041齐齐哈尔医学院附属第一医院 黑龙江 齐齐哈尔 161041齐齐哈尔医学院附属第一医院 黑龙江 齐齐哈尔 161041齐齐哈尔医学院附属第一医院 黑龙江 齐齐哈尔 161041齐齐哈尔医学院附属第一医院 黑龙江 齐齐哈尔 161041齐齐哈尔医学院附属第一医院 黑龙江 齐齐哈尔 161041
阴道微生态老年阴道炎复发风险
Vaginal microecologyElderlyVaginitisRecurrence risk
《中外医学研究》 2026 (11)
5-8,13,5
齐齐哈尔市科技计划联合引导项目(LSFGG-2025105)
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