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口服吗啡相关研究的文献计量分析:现状、热点与展望OA

Bibliometric analysis of oral morphine-related research:Current status,hotspots and prospects

中文摘要英文摘要

目的 采用文献计量学分析方法,对口服吗啡的研究现状、热点和发展趋势进行可视化分析.方法 检索Web of Science核心数据库自建库至2025年12月5日收录的与口服吗啡相关的文献,使用VOSviewer(1.6.20版)和CiteSpace(6.4.R1版)软件对发文量、国家、机构、作者、期刊和关键词进行系统分析.结果 共纳入1739篇关于口服吗啡研究领域相关文献.结果显示全球范围内关于口服吗啡的研究呈持续增长趋势,美国的发文量与被引频次均居首位.研究热点主要集中在药代动力学机制解析、癌痛规范化管理、术后多模式镇痛策略、成瘾性研究等方面.结论 吗啡作为经典阿片类镇痛药的相关研究长期受国际学界广泛关注.尽管中国在该领域已形成相当规模的研究产出,但在引领国际前沿的高影响力成果(如高被引论文)构建及深度、紧密的国际合作网络方面仍有提升空间.未来的研究与实践着力于积极拓展并深化国际合作,融入全球创新网络体系;继续推进基础药理探索与真实世界研究证据的深度融合,弥合从机制发现到临床应用的转化鸿沟,最终推动疼痛诊疗向精准化、个体化方向发展.

Objective To conduct a visual analysis of the current status,research hotspots,and prospects in oral morphine studies using bibliometric analysis methods.Methods Articles related to oral morphine were retrieved from the Web of Science core collection database from its inception to 5 December 2025.Systematic analysis of publication volume,countries,institutions,authors,journals,and keywords was conducted using VOSviewer(version 1.6.20)and CiteSpace(version 6.4.R1)software.Results A total of 1739 articles relevant to the field of oral morphine research were included.Findings indicate a sustained global growth trend in oral morphine research,with the United States leading in both publication volume and citation frequency.Research hotspots primarily focus on pharmacokinetic mechanism analysis,standardised cancer pain management,postoperative multimodal analgesic strategies,and addiction studies.Conclusion As a cornerstone of classical opioid analgesics,oral morphine has long attracted extensive international scholarly attention.Although China has achieved substantial research output in this field,there remains scope for improvement in producing high-impact outcomes(such as highly cited papers)that lead international frontiers,as well as in establishing deep,close international collaborative networks.Future research and practice should focus on actively expanding and deepening international collaboration to integrate into global innovation networks.Concurrently,efforts should continue to advance the deep integration of fundamental pharmacological exploration with real-world evidence,bridging the translational gap between mechanism discovery and clinical application.This will ultimately propel pain diagnosis and treatment towards precision and individualisation.

赵燕鸿;宋超;周梦娣;赵明玄

昆明医科大学药学院暨云南省天然药物药理重点实验室,云南 昆明 650500||昆明理工大学附属安宁市第一人民医院药物(疫苗)早期临床试验研究中心,云南 昆明 650302昆明理工大学附属安宁市第一人民医院疼痛科,云南 昆明 650302昆明理工大学附属安宁市第一人民医院药物(疫苗)早期临床试验研究中心,云南 昆明 650302昆明理工大学附属安宁市第一人民医院药物(疫苗)早期临床试验研究中心,云南 昆明 650302

医药卫生

疼痛管理口服吗啡文献计量分析阿片类药物

Pain managementOral morphineBibliometric analysisOpioids

《中国现代医生》 2026 (15)

24-28,37,6

10.3969/j.issn.1673-9701.2026.15.006

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