基于肝主疏泄理论探讨胆汁酸代谢与乳腺癌发病的相关性OA

[Objective]To reveal the intrinsic link between impaired liver Qi flow,bile acid metabolism disorders,and breast cancer development,elucidate the molecular biological basis of liver Qi stagnation-induced carcinogenesis,in order to offer new insights for the integrated prevention and treatment of breast cancer through Chinese and western medicine,based on the traditional Chinese medicine(TCM)theory of liver governing catharsis.[Methods]Systematically examining the core concept of liver regulation in promoting Qi flow,analyzing the impact of bile acid metabolism disorders on breast cancer,this research integrates TCM theory with modern medical research,establishes the theoretical logic linking"liver dysfunction in promoting smooth flow-bile acid metabolism disorder-breast cancer",and summarizes the basis for prevention and treatment with TCM based on this mechanism.[Results]Liver dysfunction in regulating Qi flow serves as the core pathogenesis,affecting the entire course of breast cancer through pathological factors such as Qi stagnation and phlegm-stasis.Modern research reveals a close association between bile acid metabolism disorders and breast cancer:under physiological conditions,specific bile acid components exert tumor-suppressing surveillance by activating Takeda G protein-coupled receptor 5(TGR5)/farnesoid X receptor(FXR);conversely,pathological imbalances in bile acid profiles and abnormal signaling create conditions conducive to breast cancer development.Impaired liver Qi regulation disrupts bile secretion and excretion,interferes with enterohepatic circulation,and disturbs gut microbiota balance,thereby inducing metabolic disorders and increasing breast cancer risk.Liver-soothing and Qi-regulating Chinese herbal medicines can correct metabolic dysregulation and inhibit tumor progression by modulating bile acid-related signaling pathways.[Conclusion]Impaired bile acid metabolism induced by abnormal liver detoxification function is associated with breast cancer development.Elucidating this mechanism will help provide an innovative therapeutic paradigm for the prevention and treatment of breast cancer through the integration of Chinese and western medicine,and also offer new directions for theoretical research and clinical practice in breast cancer prevention and treatment.