纯化米糠对D-半乳糖诱导的亚急性衰老小鼠抗氧化能力和肠道菌群的影响OA

Rice bran,a by-product of grain processing,is rich in dietary fiber and possesses valuable nutritional and functional properties.This study aimed to evaluate the physiological effects of purified rice bran(PRB),produced via α-amylase hydrolysis,on behavioral function,antioxidant capacity,and gut microbiota composition in a murine model of subacute aging induced by D-galactose(D-gal).The results showed that D-gal treatment significantly(p<0.05)impaired locomotor and cognitive functions.In contrast,PRB supplementation effectively alleviated these defi-cits dose-dependently,with the high-dose group showing the most pronounced improvement.In terms of antioxidant capacity,PRB significantly increased the superoxide dismutase(SOD)activity and glutathione(GSH)content,yet reduced malondialdehyde(MDA)content,thereby alleviating oxidative stress.Gut microbiota analysis revealed that PRB regulated microbial diversity,suppressed harmful bacteria such as Desulfovibrio,and promoted the growth of beneficial genera such as Bifidobacterium,Rikenella,promoting microbial homeostasis.Moreover,PRB significantly enhanced the production of short-chain fatty acid(SCFA),including acetic,propionic,butyric,and valeric acids,contributing to intestinal pH value regulation and homeostasis.Overall,PRB exerted synergistic effects on oxidative stress and gut dysbiosis in aging mice,suggesting its potential to promote gut health and overall well-being.