针刺治疗类风湿关节炎免疫调节机制的研究进展OA

Rheumatoid arthritis(RA),as a chronic autoimmune disease,is characterized by aberrant immune-mediated attacks on joint tissues.Acupuncture,as a traditional therapeutic modality in Chinese medicine,exerts therapeutic effects by regulating the balance of T-cell subsets,inhibiting the release of inflammatory cytokines,and modulating the neuroendocrine-immune network.In recent years,with the deepening of mechanistic studies on acupuncture,its immunoregulatory effects in RA have become increasingly evident.Acupuncture has been shown to alleviate symptoms in patients with RA through multi-target and multi-level immune regulatory mechanisms.However,existing studies are still largely limited to animal models and small-sample clinical observations,and mechanistic investigations remain relatively superficial,lacking support from high-quality evidence derived from multicenter,large-sample studies.Based on this,this study focuses on recent advances in the molecular mechanisms and signaling pathways underlying the immunoregulatory effects of acupuncture.It systematically summarizes the regulatory effects of acupuncture on key inflammatory pathways,including JAK/STAT,NF-κB,and MAPK,thereby further elucidating its advantages in multi-target and holistic regulation and providing a modern medical interpretation of the scientific basis for acupuncture in treatment of RA.