益生菌通过调节肠道菌群干预过敏性疾病的研究进展OA

Allergic diseases are disorders in which the body,mediated by immunoglobulin E(IgE),exhibits abnormal immune responses against antigens.Their pathogenesis is closely related to the excessive acti-vation of type 2 immune responses and the imbalance of immune tolerance.The gut microbiota,as the core component of the mucosal immune system,dynamically regulates the systemic immune homeostasis through mechanisms such as the"gut-skin axis"and"gut-lung axis".Its disorder is a key factor in inducing and ac-celerating the allergic process.Probiotics,as an adjunctive treatment for allergic diseases,mainly exert their effects through multiple target mechanisms such as reshaping the structure of the gut microbiota,enhancing the intestinal barrier function,regulating the metabolic products of the microbiota,and balancing the Th1/Th2 im-mune responses.This article systematically elaborates on the correlation between gut microbiota imbalance and the progression of allergic diseases,focusing on the immunoregulatory role therein and the therapeutic potential of probiotics in restoring gut microbiota homeostasis to regulate disease progression.