基线非传统血脂与脑小血管病影像总负荷对突发性耳聋预后的预测价值OA

Objective To determine values of baseline non-traditional lipid parameters and load of cerebral small vessel disease(CSVD)in the prognosis of sudden sensorineural hearing loss.Methods Hearing status in 363 patients with sudden deafness admitted to Shengli Oilfield Central Hospital from May 2020 to June 2024 were categorized as mild or moderate(n=52),moderate-severe or severe(n=160)and profound or total deafness(n=151)based on pure-tone average(PTA).Clinical manifestations and radiological features were analyzed,as well as MRI load of CSVD.Clinical characteristics and therapeutic outcomes were compared among patients with different levels of hearing loss.Results Prevalence of hypertension and diabetes,levels of total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),and ratios of total deafness,were significantly different for different the three hearing status groups(P<0.05).High MRI load of CSVD(1 points,2 points and≥3 points)and high LCI and atherogenic index of plasma(AIP)were independent risk factors for poor prognosis(P<0.05).The area under the curve(AUC)for predicting prognosis was 0.697 for MRI load of CSVD,0.560 for Castelli's risk index-I(CRI-I),0.560 for Castelli's risk index-Ⅱ(CRI-Ⅱ),0.594 for lipoprotein combine index(LCI)and 0.613 for AIP,respectively.The AUC of AIP and MRI load of CSVD combination for predicting prognosis was 0.733,significantly better than each indicator alone.Conclusions MRI load of CSVD and non-traditional blood lipid parameters such as AIP and LCI are useful indicators for assessing the prognosis of sudden deafness,and their combination can significantly enhance predictive efficacy.