通关藤注射液致不良反应文献分析OA
Literature Analysis of Adverse Drug Reactions Induced by Tongguanteng Injection
目的:研究通关藤注射液引起药品不良反应(ADR)的临床特征、导致因素及防范措施,为临床用药安全性的提升提供依据.方法:通过计算机检索中国知网数据库、万方数据库、维普中文科技期刊数据库、PubMed、Web of Science 及 EMbase,检索建库至 2025 年 8 月收录的通关藤注射液致不良反应的病例报道,对其进行整理并对有关数据进行描述性分析.结果:共检索到通关藤注射液致不良反应的文献 8 篇,涉及患者病例 22 例,男女比例为 1:1;≥50 岁患者居多,用药 1 h 内发生的药品不良反应较多,严重者出现过敏性休克(1 例),类过敏反应(1 例),严重不良反应(2 例),其余均为胸闷、憋喘、腹泻等轻度不良反应.本次分析共检出 10 例说明书未记载的新不良反应,包括心率加快 2 例、心率过快 2 例、心前区刺痛 1 例、心律失常 1 例、皮肤水肿 1 例、类过敏样反应 1 例、眼部流泪 1 例、眼部红肿 1 例,占比 15.9%,补充了该药的不良反应监测数据.结论:临床应重视通关藤注射液的不良反应,加强临床用药的监护,从而保证患者用药安全.
OBJECTIVE:To investigate the clinical characteristics,leading factors and countermeasures of adverse drug reactions(ADR)induced by Tongguanteng injection,and to provide references for improving clinical medication safety.METHODS:Case reports on ADR induced by Tongguanteng injection from database establishment to Aug.2025 were collected by retrieving CNKI,Wanfang,VIP,PubMed,Web of Science and EMbase databases,descriptive analysis was conducted on relevant data.RESULTS:A total of 8 studies related to ADR induced by Tongguanteng injection were retrieved,including 22 patients,with a male-to-female ratio of 1∶1.Most patients were aged≥50 years.ADR mostly occurred within 1 h after administration,severe cases included anaphylactic shock(1 case),anaphylactoid reaction(1 case),severe adverse drug reactions(2 cases),the rest were mild ADR such as chest distress,dyspnea and diarrhea.A total of 10 new ADR not recorded in drug instructions were detected,including 2 cases of increased heart rate,2 cases of tachycardia,1 case of precordial stabbing pain,1 case of arrhythmia,1 case of skin edema,1 case of anaphylactoid-like reaction,1 case of eye tearing,and 1 case of eye redness and swelling,accounting for 15.9%,which had supplemented the ADR monitoring data of the drug.CONCLUSIONS:Clinicians should pay close attention to ADR induced by Tongguanteng injection,and strengthen medication monitoring to ensure medication safety.
姜荣荣;杭永付;袁芳
苏州市中西医结合医院药剂科,江苏 苏州 215101苏州大学附属第一医院药学部,江苏 苏州 215000苏州市中西医结合医院肝病科,江苏 苏州 215101
医药卫生
通关藤注射液消癌平注射液药品不良反应抗肿瘤文献分析
Tongguanteng injectionXiaoaiping injectionAdverse drug reactionsAntitumorLiterature analysis
《中国医院用药评价与分析》 2026 (5)
631-634,4
江苏省省级中医重点专科(肝病科)(No.苏中医医政[2023]5号)
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