药学服务干预对首发精神分裂症患者用药依从性的影响OA
Effect of Pharmaceutical Care Intervention on Medication Adherence in Patients with First-Episode Schizophrenia
目的 探讨药学服务干预对首发精神分裂症(SCH)患者用药依从性的影响及其因素.方法 选取医院2020年1月至2023年6月收治的首发 SCH 患者 80 例,按随机数字表法分为对照组和研究组,各 40 例.两组患者均予利培酮口崩片治疗,在此基础上,对照组患者实施常规干预,研究组患者实施药学服务干预.比较两组患者的用药依从性,采用单因素分析法分析用药依从性的影响因素,并采用二元 Logistic 回归分析法分析用药依从性的危险因素和保护因素.结果 研究组患者的用药总依从率显著高于对照组(92.50%比65.00%,P＜0.05).用药依从性的影响因素包括干预方式、年龄、疾病相关知识、对医师信任程度、家庭支持、月收入、用药种类、每日用药频次、定期随访.其中,年龄≥60 岁、缺乏疾病相关知识、常规干预是首发 SCH 患者用药依从性的危险因素(P＜0.05),家庭支持是首发 SCH 患者用药依从性的保护因素(P＜0.05).结论 药学服务干预可提高首发 SCH 患者的用药依从性,其用药依从性与年龄、疾病相关知识、是否采用药学服务干预、是否有家庭支持有关.
Objective To investigate the effect and factors of pharmaceutical care intervention on medication adherence in patients with first-episode schizophrenia(SCH).Methods A total of 80 patients with first-episode SCH admitted to the hospital from January 2020 to June 2023 were selected and randomly divided into the control group and the study group by the random number table method,with 40 cases in each group.The patients in the two groups were treated with Risperidone Orally Disintegrating Tablets.On this basis,the patients in the control group received routine intervention,while the patients in the study group received pharmaceutical care intervention.The patients' medication adherence in two groups was compared,the influencing factors of medication adherence were analyzed by the univariate analysis,and the risk factors and the protective factors for medication adherence were analyzed by the binary Logistic regression analysis.Results The overall medication adherence rate in the study group was significantly higher than that in the control group(92.50%vs.65.00%,P＜0.03).The influencing factors of medication adherence included intervention methods,age,disease-related knowledge,trust in physicians,family support,monthly income,medication types,daily medication frequency,and regular follow-up.Among them,age≥60 years old,lack of disease-related knowledge,and routine intervention were risk factors for medication adherence in patients with first-episode SCH(P＜0.05),while family support was a protective factor for medication adherence in patients with first-episode SCH(P＜0.05).Conclusion Pharmaceutical care intervention can improve medication adherence in patients with first-episode SCH,which is related to age,disease-related knowledge,whether to conduct the pharmaceutical care intervention,and whether there is family support.
杨淇茗;袁晓燕;陈彦清;张晓庆;罗刚
四川省攀枝花市中心医院,四川 攀枝花 617000四川省攀枝花市中心医院,四川 攀枝花 617000四川省攀枝花市中心医院,四川 攀枝花 617000四川省攀枝花市中心医院,四川 攀枝花 617000四川省攀枝花市中心医院,四川 攀枝花 617000
医药卫生
药学服务干预精神分裂症用药依从性
first-episodeschizophreniapharmaceutical care interventionmedication adherence
《中国药业》 2026 (11)
6-9,4
四川省预防医学会第二届静脉药物配制科研(孵化)项目[川预学-静配-2020-005].
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