中药活性成分靶向肠道菌群代谢物调控肿瘤的研究进展OA

Malignant tumors have become a major global health threat.Conventional therapies such as chemotherapy and radio-therapy are limited in clinical application and efficacy improve-ment due to prevalent limitations including drug resistance,poor targeting,and severe toxic side effects.This article sys-tematically reviews the functional characteristics of traditional Chinese medicine(TCM)active ingredients in regulating gut microbiota and their metabolites,as well as the impact of this regulatory network on tumor progression,aiming to provide new directions for the research on TCM active ingredients in anti-tumor therapy.Through the review,it is found that TCM active ingredients can effectively reshape the gut microbiota ecology and significantly alter the levels and composition of microbial metabolites in the host.As key signaling molecules,these me-tabolites can directly or indirectly inhibit the proliferation and metastasis of tumor cells and improve the tumor microenviron-ment through multiple pathways,such as regulating the body's immune-inflammatory response,maintaining intestinal barrier function,and affecting energy metabolism.Therefore,in-depth clarification of the mechanism by which TCM active ingredients regulate tumor progression through gut microbiota and their me-tabolites will lay a theoretical foundation for the future develop-ment of novel strategies for tumor prevention and treatment based on microbiota regulation.