携载细胞外囊泡水凝胶在伤口愈合中的构建策略与应用前景OA
Fabrication strategies and application prospects of hydrogels carrying extracellular vesicles in wound healing
复杂伤口的有效治疗是临床重大挑战.细胞外囊泡(extracellular vesicles,EVs)在促进组织修复、调节免疫反应和加速伤口愈合方面展现出巨大潜力,但EVs在体内容易被快速清除,疗效受限.水凝胶能有效保护并延长EVs在伤口部位的滞留时间,通过响应pH、酶或活性氧(reactive oxygen species,ROS)等微环境信号实现EVs智能可控释放,为EVs的靶向与持续递送提供了理想的解决方案.该文综述了不同来源的EVs在伤口愈合中的作用及机制,其智能响应型载体系统的构建策略,以及在复杂伤口中的应用.
Effective treatment of complex wounds is a major clinical challenge.Extracellular vesicles(EVs)have shown great potential in promoting tissue repair,modulating immune responses,and accelerating wound healing,but they are easily cleared rapidly in vivo,limiting their efficacy.Hydrogels can ef-fectively protect EVs and prolong their retention time at wound sites,achieving intelligent and controlled release of EVs in re-sponse to microenvironmental signals such as pH,enzymes,or reactive oxygen species(ROS),providing an ideal solution for targeted and sustained delivery of EVs.This article reviews the mechanisms by which EVs from different sources promote wound healing,strategies for constructing their smart respon-sive carrier systems,and their applications in complex wounds.
杨艳伟;王上;霍利月;张小琳;张钰蓓;汪雪峰
江苏大学附属医院中心实验室,江苏 镇江 212001慈济国际中医学院,不列颠哥伦比亚省温哥华 V6H1G7江苏大学附属医院中心实验室,江苏 镇江 212001江苏大学附属医院中心实验室,江苏 镇江 212001江苏大学附属医院中心实验室,江苏 镇江 212001江苏大学附属医院中心实验室,江苏 镇江 212001
医药卫生
细胞外囊泡水凝胶智能响应伤口愈合复杂伤口再生医学
extracellular vesicleshydrogelintelligent re-sponsewound healingcomplex woundsregenerative medi-cine
《中国药理学通报》 2026 (5)
817-824,8
国家自然科学基金资助项目(No 81871243)江苏省社会发展项目(No BE2017697)江苏省"六大人才高峰"项目(No WSN-009)镇江市中医妇科病临床医学研究中心开放课题(No SS202204-KFB02)
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