蛋白质肉豆蔻酰化修饰在肿瘤发生发展中的研究进展OA
Research progress of protein N-myristoylation in tumorigenesis and progression
蛋白质肉豆蔻酰化修饰是一种重要的翻译后修饰,由N-肉豆蔻酰转移酶(N-myristoyltransferase,NMT)催化,将肉豆蔻酸共价连接至蛋白质N端的甘氨酸残基,从而调控其膜定位、稳定性及生物学功能.该研究旨在综述该修饰的分子机制及其在肿瘤发生发展中的作用,分析蛋白质肉豆蔻酰化修饰在肿瘤中的异常表达模式、信号通路调控、代谢调控及与其他翻译后修饰的互作关系.研究表明,该修饰在肝癌、肺癌、乳腺癌、前列腺癌等多种实体瘤中呈异常表达,参与调控肿瘤细胞的增殖、迁移、耐药及免疫逃逸等恶性行为.
Protein N-myristoylation is an important post-translational modification catalyzed by N-myristoyltransferase(NMT),which covalently attaches myristic acid to the N-terminal glycine residue of target proteins,thereby regulating their membrane localization,stability,and biological func-tions.This review aims to summarize the molecular mechanisms of protein N-myristoylation and its role in tumor progression,analyzing the abnormal expression patterns of protein N-myristoylation in tumors,its regulation of signaling pathways and metabolism,and its interactions with other post-translational modifications.The study shows that this modifica-tion is aberrantly expressed in multiple solid tumors such as he-patocellular carcinoma,lung cancer,breast cancer,and pros-tate cancer,and participates in regulating tumor cell prolifera-tion,migration,drug resistance,and immune evasion.
赵雅然;彭倩;杜沅沁;叶一娴;吴龙达;伍师坚;韦燕飞
广西中医药大学基础医学院||广西高发传染病中西医结合转化医学重点实验室广西中医药大学基础医学院||广西高发传染病中西医结合转化医学重点实验室广西高发传染病中西医结合转化医学重点实验室||广西中医药大学第一附属医院脾胃肝病科,广西 南宁 530022广西中医药大学基础医学院||广西高发传染病中西医结合转化医学重点实验室广西中医药大学基础医学院||广西高发传染病中西医结合转化医学重点实验室广西中医药大学基础医学院||广西高发传染病中西医结合转化医学重点实验室广西中医药大学基础医学院
医药卫生
蛋白质肉豆蔻酰化修饰蛋白质翻译后修饰N-肉豆蔻酰转移酶肿瘤信号通路靶向治疗
protein N-myristoylationprotein translational modificationsN-myristoyltransferasetumorssignaling path-waystargeted therapy
《中国药理学通报》 2026 (5)
806-811,6
国家自然科学基金资助项目(No 82260786)广西中医药大学研究生教育创新计划项目(No YCSW2025436)
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