3级高血压患者E/e'比值与预后的相关性OA
Correlation between E/e'ratio and prognosis in patients with stage 3 hypertension
目的 探讨3级高血压患者二尖瓣口舒张早期血流峰值速度与二尖瓣环侧壁、室间隔舒张早期血流峰值速度平均值之比(E/e'比值)比值与预后的关系.方法 选取2022年1月1日至2024年1月1日于河北医科大学第一医院心脏中心就诊的500例3级高血压患者,根据超声心动图中测得的E/e'比值分为正常组(<8)、中间组(8～14)和升高组(>14),观察3组患者的左室射血分数(LVEF)、左心室舒张末内径(LVEDD)、左心室收缩末内径(LVESD)、左心房前后径(LAD)、室间隔厚度(IVS)情况,随访3组患者1年内主要不良心脑血管事件(MACCE)的发生情况,包括心脏死亡、心肌梗死、心力衰竭、短暂性脑缺血发作、脑梗死、脑出血.结果 3组患者的LVEF、LVEDD、LVESD、LAD、IVSD总体比较差异有统计学意义(均P<0.05).与正常组和中间组比较,升高组上述指标差异均有统计学意义(均P<0.05).3组患者总MACCE发生率差异有统计学意义(P<0.001).Kaplan-Meier生存曲线分析显示,升高组累积生存率显著低于正常组和中间组(P<0.001).logistic分析结果显示,1年内MACCE发生率仅与E/e'比值相关(OR=5.468,95%CI:1.909～15.657,P=0.002),E/e'>14是3级高血压患者1年内MACCE发生的独立危险因素.结论 E/e'比值与3级高血压患者预后显著相关.
Objective To investigate the relationship between the ratio of early diastolic mitral inflow velocity to the average early diastolic mitral annular tissue velocity at the septal and lateral walls(E/e'ratio)and prognosis in patients with grade 3 hypertension.Methods A total of 500 patients with grade 3 hypertension who visited the Heart Center of the First Hospital of Hebei Medical Univer-sity from January 1,2022,to January 1,2024,were selected.Based on the E/e'ratio measured using echocardiography,patients were divided into the normal(<8),intermediate(8-14),and elevated(>14)groups.The left ventricular ejection fraction(LVEF),left ventricular end-diastolic dimension(LVEDD),left ventricular end-systolic dimension(LVESD),left atrial anteroposterior diameter(LAD),and inter-ventricular septal thickness(IVS)were assessed in the three groups.Patients were followed up for major adverse cardiac and cerebrovas-cular events(MACCE;including cardiac death,myocardial infarction,heart failure,transient ischemic attack,cerebral infarction,and cerebral hemorrhage)within 1 year.Results Comparisons of LVEF,LVEDD,LVESD,LAD,and IVSD among the three groups showed statistically significant differences(all P<0.05).Pairwise comparisons revealed that the elevated group showed statistically significant dif-ferences in the above parameters compared with the normal and intermediate groups(all P<0.05).The incidence of total MACCE among the three groups was statistically significant(P<0.001).Kaplan-Meier survival curve analysis revealed that the cumulative survival rate of the elevated group was significantly lower than that of the normal and intermediate groups(P<0.001).Logistic regression analysis showed that the incidence of MACCE within 1 year was only associated with the E/e'ratio(OR=5.468,95%CI:1.909-15.657,P=0.002),and that E/e'>14 was an independent risk factor for the occurrence of MACCE within 1 year in patients with grade 3 hypertension.Conclusion The E/e'ratio is significantly associated with the prognosis of patients with grade 3 hypertension.
李晓燕;李国栋;赵君乐;杨志瑜;张宁;李柳
河北医科大学第一医院 心脏中心,石家庄 050011河北医科大学第一医院 教务处,石家庄 050011河北医科大学第一医院 教务处,石家庄 050011河北医科大学第一医院 心脏中心,石家庄 050011河北医科大学第一医院 超声科,石家庄 050011河北医科大学第一医院 心脏中心,石家庄 050011
医药卫生
3级高血压超声心动图E/e'比值
stage 3 hypertensionechocardiographyE/e'ratio
《中国医科大学学报》 2026 (5)
423-426,431,5
河北省卫生健康委员会重点科技研究计划(20241849)
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