SREBP在代谢功能障碍相关脂肪性肝病的作用及靶向干预OA
The role of sterol regulatory element-binding proteins in metabolic dysfunction-associated steatotic liver disease and targeted interventions
代谢功能障碍相关脂肪性肝病(MASLD)是一种全球性的健康问题,其特征是肝脏脂质过度积累、胰岛素抵抗(IR)和氧化应激.固醇调节元件结合蛋白(SREBP),特别是 SREBP-1c 和 SREBP-2,是脂质合成和胆固醇代谢的关键转录调控因子.越来越多的证据表明,SREBP 通过调控脂质生成、参与胰岛素信号通路的相互作用,并调节内质网应激(ERS)及氧化应激,在 MASLD 的发病机制中起着核心作用.本文通过探讨SREBP 在 MASLD 发病机制中的作用及其相关影响因素和治疗策略,为深入理解 MASLD 的发病机制以及开发靶向 SREBP 的治疗新策略提供了重要的参考价值.
Metabolic dysfunction-associated steatotic liver disease(MASLD)represents a global health issue characterized by excessive hepatic lipid accumulation,insulin resistance,and oxidative stress.Sterol regulatory element-binding proteins(SREBP),particularly SREBP-1c and SREBP-2,are key transcriptional regulators of lipid synthesis and cholesterol metabolism.Growing evidence indicates that SREBPs play a central role in MASLD pathogenesis by modulating lipogenesis,interacting with insulin signaling,and regulating endoplasmic reticulum and oxidative stress.This review explores the role of SREBPs in MASLD pathogenesis,along with related influencing factors and therapeutic strategies,providing valuable insights for a deeper understanding of the disease mechanisms and for the development of novel SREBP-targeted treatments.
程丛丛;康晨阳;王雅媛;陈丽
湖北中医药大学针灸骨伤学院,武汉 430061湖北中医药大学针灸骨伤学院,武汉 430061湖北中医药大学针灸骨伤学院,武汉 430061湖北中医药大学针灸骨伤学院,武汉 430061
医药卫生
SREBPMASLD脂质代谢肠道菌群昼夜节律靶向治疗
SREBPMASLDlipid metabolismgut microbiotacircadian rhythmtargeted therapy
《中国比较医学杂志》 2026 (10)
88-98,119,12
国家自然科学基金(82305401)湖北省自然科学基金(2023AFD140).
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