合肥地区献血者抗-TP检测与合并感染情况分析OA

Objective To analyze the status of Treponema pallidum(TP)infection among blood donors in Hefei area by evaluating anti-TP reactive donors,and to provide data support for blood screening strategies,evaluation of reagent appli-cation,and public health prevention and control strategies.Methods TPPA confirmation test were performed on 338 anti-TP positive samples of voluntary blood donors at Anhui Blood Center from February to April 2022,July to October 2022,February to June 2023.RPR tests were conducted on samples positive for TPPA.The test results,co-reactivity of TP with HBV,HCV,and HIV,and demographic characteristics of the donors were statistically analyzed.Results The unqualified rate of anti-TP among blood donors in Hefei area was 0.30%(405/133 587),and the positive rate for TPPA was 67.46%(228/338).Among the TPPA-positive donors,31.67%were RPR-positive.The co-positive rates of HBV,HCV and HIV in anti-TP reactive blood donors were 0.74%(3/405),0.49%(2/405),and 1.73%(7/405),respectively,with HIV co-positivity being the most common.Most co-positive donors were males aged 31-50 years with a high school education or low-er,and all were first-time whole blood donors.Conclusion The anti-TP unqualified rate among blood donors in Hefei area is at a low-to-mederate level.HIV is the most common co-infection with TP among anti-TP positive donors.The majority of co-infected donors are middle-aged men donating whole blood for the first time.