基于处方前置审核系统的G6PD缺乏症患者用药安全审核体系的构建与应用OA

AIM To construct an audit system based on the pre-prescription review system for medication safety in patients with glucose-6-phosphate dehydrogenase(G6PD)deficiency,aiming to standardize physician prescribing practices and ensure patient medication safety.METHODS A G6PD deficiency contraindicated medication database(including Chinese and Western medicines)was integrated and embedded into the pre-prescription review module of the Medicom PASS system.Graded alert rules were established based on drug contraindication levels(contraindicated/use with caution),and real-time prescription interception was implemented via a three-tier review mechanism.RESULTS Over 5 months of operation,the system intercepted 63 inappropriate prescriptions containing contraindicated medications(involving 19 distinct drugs),achieving a 100％alert trigger rate.Physicians subsequently adjusted medication regimens in 55.56％of these cases.The system performed each interception within 1 to 2 seconds,while the average time required for online pharmacist review was 13.01 seconds per order.Compared to the period before the implementation of the audit system based on the pre-prescription review system for medication safety,prescription review efficiency demonstrated a significant improvement.CONCLUSION Based on the pre-prescription review system,the disease-specific medication safety review framework significantly reduces medication errors in patients with G6PD deficiency.Its graded alert mechanism effectively balances medication safety with clinical flexibility,overcoming the limitations of traditional manual review.This model provides an empirical reference for hospitals to establish cost-effective and efficient medication safety systems,contributing to the optimization of pharmacist review efficiency and clinical rational medication use levels.