拉萨市血流感染病原菌分布及耐药性分析OA

Objective To understand the distribution and antimicrobial resistance of pathogens from patients with bloodstream infection(BSI)in Lhasa City,and to provide basis for antimicrobial use in clinical practice.Methods The distribution and antimicrobial resistance results of pathogens isolated from blood culture specimens from the Tibet Autonomous Region People's Hospital from July 2019 to October 2024 were analyzed retrospectively.Results A total of 24 597 blood specimens were cultured and identified,1 097 strains of pathogens were isolated,with an overall positive rate of 4.5%.Gram-positive bacteria,Gram-negative bacteria,and fungi were 626,442,and 29 strains,respectively,accounting for 57.1%,40.3%,and 2.6%.The detection rates of methicillin-resistant Staphyloco-ccus aureus(MRSA)and methicillin-resistant coagulase negative Staphylococcus(MRCNS)were 45.1%and 83.5%,respectively.Among the isolated Staphylococcus aureus and coagulase-negative Staphylococcus(CNS),there were no vancomycin-and linezolid-resistant strains.Among Escherichia coli and Klebsiella pneumoniae,detection rates of extended-spectrum β-lactamases(ESBLs)-producing strains were 59.3%and 35.0%,respectively.The detection rate of carbapenem-resistant Enterobacterales was low,with a detection rate of 2.4%.Conclusion Antimicrobial spectrum of pathogens detected from blood culture is broad,and there are significant differences in antimicrobial resistance among different pathogens.Surveillance should be strengthened,and antimi-crobial use should be standardized.