帕金森病冲动控制障碍的神经影像研究进展OA
Advances in neuroimaging studies of impulse control disorders in Parkinson disease
帕金森病(PD)是以黑质-纹状体多巴胺能通路变性为主要病理改变的神经系统变性疾病,主要表现为运动功能障碍.然而,近年来,越来越多的研究开始关注PD的非运动症状,其中,冲动控制障碍(ICD)作为PD最常见的非运动症状之一,严重影响患者的生活质量.ICD的发病机制及危险因素较为复杂,至今尚未完全明确.但是,随着影像技术的发展,神经影像技术可以帮助评估PD-ICD患者的大脑结构和功能,从而探索ICD的发病机制、诊断和治疗.因此,本文主要就PD-ICD的神经影像研究进展进行综述.
Parkinson disease(PD)is a degenerative disease of the nervous system with the main pathological change of nigral-striatal dopaminergic pathway degeneration,mainly manifesting as motor dysfunction.However,in recent years,more and more studies have started to investigate the non-motor symptoms of PD,among which impulse control dis-orders(ICD),as one of the most common non-motor symptoms of PD,seriously affects the quality of life of patients.ICD has complex pathogenesis and risk factors,which remain unclear at present.With the development of imaging technology,neuroimaging techniques can help to evaluate the brain structure and function of PD-ICD patients,thereby helping to ex-plore the pathogenesis of ICD and assist in its diagnosis and treatment.Therefore,this article reviews the advances in neu-roimaging studies of ICD in PD.
王新平;郎文娟;袁永胜
南京医科大学第一附属医院神经内科,江苏 南京 210029青岛市市立医院神经内科,山东 青岛 266000南京医科大学第一附属医院神经内科,江苏 南京 210029
医药卫生
帕金森病冲动控制障碍神经影像
Parkinson diseaseImpulse control disordersNeuroimaging
《中风与神经疾病杂志》 2026 (5)
412-416,5
国家自然科学基金资助项目(81901297,82471268)江苏省人民医院(南京医科大学第一附属医院)临床能力提升工程项目(JSPH-MC-2022-25)
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