帕金森病肌强直的研究进展:从机制到评估OA

Rigidity is a core motor symptom of Parkinson disease(PD),characterized by uniformly increased resis-tance during passive muscle stretching.It can be classified into two types:lead-pipe rigidity and cogwheel rigidity.This re-view systematically summarizes the pathophysiological mechanisms underlying rigidity in PD,including enhanced long-latency stretch reflexes,the combined effects of shortening reaction and stretch-induced inhibition,functional abnormali-ties in brainstem and cortico-basal ganglia-cerebellar circuit,and alterations in muscle biomechanical properties.This re-view also summarizes recent advances in objective assessment methods such as electromyography,ultrasound elastogra-phy,servo motors,and inertial sensors.Studies indicate that rigidity in PD results from the interaction between abnormal neural regulation and changes in muscle biomechanical properties,with assessment methods evolving from subjective clini-cal scoring toward multimodal objective quantification.A deeper understanding of the mechanisms and assessment methods of rigidity is crucial for the diagnosis and treatment of PD.