药物性震颤的表面肌电特点OA

Objective To investigate the surface electromyography(sEMG)characteristics of drug-induced tremor,and to identify electrophysiological biomarkers for differentiating it from tremor caused by Parkinson disease(PD).Methods A total of 50 patients with drug-induced tremor and 71 patients with PD were enrolled.The sEMG sig-nals from bilateral radial wrist extensors and flexors,along with accelerometer signals,were recorded under resting and pos-tural conditions.Tremor frequency,amplitude,contraction pattern,and harmonic resonance were analyzed.Results The pa-tients in the drug-induced tremor group exhibited symmetrical bilateral tremor,with a higher proportion of patients with mandibular tremor compared with the PD group(70%vs 42.25%,χ2=9.09,P=0.003).Compared with the PD group,the drug-induced tremor group had a significantly higher tremor frequency under both resting and postural conditions[(6.43±0.41)Hz/(6.57±0.33)Hz vs(4.68±0.27)Hz,F=620.64,P<0.001],while there was no significant difference in tremor amplitude.Compared with the PD group,the drug-induced tremor group had a significantly lower proportion of patients with alternating contraction pattern under both resting(χ2=23.20,P<0.001)and postural(χ2=27.52,P<0.001)condi-tions,as well as a significantly lower proportion of patients with harmonic resonance under both resting(χ2=26.64,P<0.001)and postural(χ2=22.32,P<0.001)conditions.Conclusion Drug-induced tremor has the following electrophysi-ological features:bilateral symmetry,a higher prevalence rate of mandibular tremor,a higher tremor frequency,and a lower proportion of patients with alternating contraction pattern and harmonic resonance,which can provide objective evidence for differentiating drug-induced tremor from PD in clinical practice.