Isoquinoline alkaloids in Coptis chinensis to treat Alzheimer's disease through promoting growth of Bifidobacterium breve inhibiting abnormal autophagy using a novel AI high-content intelligent imaging systemOA

作者：Siqi Gu;Wei Yin;Minzhen Xie;Chengbing He;Yuntong Bian;Lin Li;Wanying Lu;Qi Wang

作者单位：Department of Medicinal chemistry and natural medicinal chemistry,College of Pharmacy,Harbin Medical University,Harbin 150081,ChinaDepartment of Medicinal chemistry and natural medicinal chemistry,College of Pharmacy,Harbin Medical University,Harbin 150081,ChinaDepartment of Medicinal chemistry and natural medicinal chemistry,College of Pharmacy,Harbin Medical University,Harbin 150081,ChinaDepartment of Medicinal chemistry and natural medicinal chemistry,College of Pharmacy,Harbin Medical University,Harbin 150081,ChinaDepartment of Medicinal chemistry and natural medicinal chemistry,College of Pharmacy,Harbin Medical University,Harbin 150081,ChinaDepartment of Medicinal chemistry and natural medicinal chemistry,College of Pharmacy,Harbin Medical University,Harbin 150081,ChinaDepartment of Medicinal chemistry and natural medicinal chemistry,College of Pharmacy,Harbin Medical University,Harbin 150081,ChinaDepartment of Medicinal chemistry and natural medicinal chemistry,College of Pharmacy,Harbin Medical University,Harbin 150081,China||State Key Laboratory of Natural and Biomimetic Drugs,Peking University,Beijing 100000,China

中文关键词：Bifidobacterium breveCoptis chinensis Franch.magnoflorine13-methylberberinepalmatrubine

英文关键词：Bifidobacterium breveCoptis chinensis Franch.magnoflorine13-methylberberinepalmatrubine

刊名：《中草药（英文版）》 2026 (2)

页码/页数：405-419,15

基金：This work was supported by the National Natural Science Foun-dation of China(No.82003919)and the State Key Laboratory of Natural and Biomimetic Drugs.Funders had no role in design of the study,collection of the data,analysis,or decision to publish the manuscript.

DOI：10.1016/j.chmed.2026.02.003