益气芪药汤联合短期胰岛素强化治疗对2型糖尿病患者血糖波动及胰岛素抵抗的影响OA
Effects of Yiqi Qiyao Decoction Combined with Short-term Intensive Insulin Therapy on Blood Glucose Fluctuation and Insulin Resistance in Patients with Type 2 Diabetes Mellitus
目的 研究 2 型糖尿病患者应用益气芪药汤+短期胰岛素强化治疗对其血糖波动及胰岛素抵抗的影响.方法 以随机数字表法将我院 2022 年 1 月-2024 年 1 月诊治的 125 例 2 型糖尿病患者分为对照组(n=63)和研究组(n=62),对照组采用短期胰岛素强化治疗,研究组在对照组基础上开展益气芪药汤治疗,对比两组治疗总有效率、血糖指标波动情况、血糖波动指标、胰岛素抵抗、空腹胰岛素、不良反应发生率.结果 研究组治疗总有效率(95.16%)较对照组(82.54%)更高(P＜0.05);与治疗前相比,两组空腹血糖、餐后 2h血糖、糖化血红蛋白均降低,且与对照组相比,研究组更低(P＜0.05);与治疗前相比,两组平均血糖、高血糖时间均降低,且与对照组相比,研究组更低(P＜0.05);两组胰岛素抵抗指数、空腹胰岛素均小于治疗前,且研究组小于对照组(P＜0.05);研究组不良反应发生率与对照组无差异(P＞0.05).结论 益气芪药汤与短期胰岛素强化治疗 2 型糖尿病可有效控制血糖波动,提高治疗总有效率,降低胰岛素抵抗指数,且临床不良反应轻,是一种有效的中西医联合治疗方案.
Objective To study the effects of Yiqi Qiyao decoction+short-term intensive insulin therapy on blood glucose fluctuation and insulin resistance in type 2 diabetes mellitus patients.Methods From January 2022 to January 2024,125 patients with type 2 diabetes mellitus enrolled in our hospital were randomized into a control group(n=63)and a study group(n=62)by random number table method.In the control group,patients were treated with short-term intensive insulin therapy.On the basis of the regimen adopted in the control group,patients in the study group were additionally treated with Yiqi Qiyao decoction.The total effective rate,fluctuation of blood glucose index,fluctuation of blood glucose index,insulin resistance,fasting insulin and incidence of adverse reactions were compared between the two groups.Results Compared with the control group(82.54%),the study group achieved a significantly higher total effective rate of treatment(95.16%)(P＜0.05).Both groups presented reductions in fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin after treatment,those indexes were markedly lower in the study group versus the control group(P＜0.05).The average blood glucose and hyperglycemia time of the two groups were lower than those before treatment,and those of the study group were lower than those of the control group(P＜0.05).The insulin resistance index and fasting insulin in the two groups were lower than those before treatment,and those in the study group were smaller than those in the control group(P＜0.05).The incidence of adverse reactions showed no significant difference between the study group and the control group(P＞0.05).Conclusion Yiqi Qiyao decoction and short-term intensive insulin therapy for type 2 diabetes mellitus can effectively control blood glucose fluctuations,improve the total effective rate of treatment,reduce insulin resistance index,and have mild clinical adverse reactions.It is an effective combination of traditional Chinese medicine and Western medicine.
张慧;王妍芸;葛艳杰
天津市滨海新区大港中医医院 内分泌科,天津 300270天津市滨海新区大港中医医院 康复科,天津 300270天津市滨海新区大港中医医院 皮肤科,天津 300270
医药卫生
益气芪药汤短期胰岛素2 型糖尿病血糖波动胰岛素抵抗
Yiqi Qiyao decoctionShort-term insulinType 2 diabetes mellitusBlood glucose fluctuationInsulin resistance
《医学信息》 2026 (10)
140-143,4
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