腺病毒感染患儿细胞因子及淋巴细胞亚群与病情预后的相关性研究OA

Objective To investigate the correlation between the levels of cytokines and lymphocyte subsets in children with adenovirus infection and the prognosis of the disease,and to provide a theoretical basis for clinical diagnosis,treatment and prognosis evaluation.Methods From February 2023 to January 2025,33 children with adenovirus infection and 33 children without adenovirus infection admitted to Anyuan County People's Hospital during the same period were selected as the research objects.They were divided into infection group and non-infection group.The levels of serum interleukin-2(IL-2),IL-4,IL-6,IL-10,tumor necrosis factor(TNF)and interferon-γ(IFN-γ)were detected by flow cytometry.The ratio of CD3+,CD4+,CD8+and CD4+/CD8+in peripheral blood was detected by flow cytometry.The correlation between the above indexes and the prognosis of the disease was analyzed.Results The levels of IL-2,IL-4,IL-6,IL-10 and TNF in the infected group were higher than those in the non-infection group,while the levels of IFN-γ were lower than those in the non-infection group(P＜0.05).The levels of lymphocyte subsets in the infected group were lower than those in the non-infection group(P＜0.05).Correlation analysis showed that the levels of IL-2,IL-4,IL-6,IL-10 and TNF were positively correlated with the prognosis of children with adenovirus infection(r=0.653,0.584,0.727,0.682,0.754,P＜0.05).The levels of IFN-γ,CD3+,CD4+,CD8+and CD4+/CD8+were negatively correlated with the prognosis of children with adenovirus infection(r=-0.626,-0.554,-0.608,-0.506,-0.703,P＜0.05).Conclusion The levels of cytokines and lymphocyte subsets in children with adenovirus infection are closely related to the prognosis of the disease,which can be used as potential biomarkers and therapeutic targets to provide new ideas for improving the prognosis of children.