Uncovering the covalent inhibitors of SARS-CoV-2 Mpro in Tibetan edible herb Rhodiola crenulata and their synergistic anti-Mpro mechanismOA
Uncovering the covalent inhibitors of SARS-CoV-2 Mpro in Tibetan edible herb Rhodiola crenulata and their synergistic anti-Mpro mechanism
Guang-Hao Zhu;Ya-Ni Zhang;Yuan Xiong;Xu-Dong Hou;Qing-Guang Zhang;Zhao-Qin Zhang;Xiao-Yu Zhuang;Wei-Dong Zhang;Guang-Bo Ge
Shanghai Frontiers Science Center of TCM Chemical Biology,Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai,201203,ChinaShanghai Frontiers Science Center of TCM Chemical Biology,Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai,201203,ChinaShanghai Frontiers Science Center of TCM Chemical Biology,Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai,201203,ChinaShanghai Frontiers Science Center of TCM Chemical Biology,Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai,201203,ChinaShanghai Frontiers Science Center of TCM Chemical Biology,Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai,201203,ChinaShanghai Frontiers Science Center of TCM Chemical Biology,Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai,201203,ChinaExperiment Center for Science and Technology,Shanghai University of Traditional Chinese Medicine,Shanghai,201203,ChinaShanghai Frontiers Science Center of TCM Chemical Biology,Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai,201203,ChinaShanghai Frontiers Science Center of TCM Chemical Biology,Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai,201203,China
SARS-CoV-2 MproRhodiola crenulata rootCovalent inhibitorSynergistic effectAllosteric inhibitionCooperative modification
SARS-CoV-2 MproRhodiola crenulata rootCovalent inhibitorSynergistic effectAllosteric inhibitionCooperative modification
《药物分析学报（英文）》 2026 (2)
473-487,15
This work was financially supported by the National Natural Science Foundation of China(Grant Nos.:82141203,82273897,U23A20516,82204606,and 82104281),the Organizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine,China(Grant No.:2023YZZ02),Shanghai Municipal Health Commission's TCM Research Project,China(Grant No.:2022CX005),Shanghai Science and Technology Innovation Action Plans,China(Grant No.:21S21900600),the Organizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine,China(Grant No.:2023YZZ02),Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine,China(Grant No.:ZYYCXTD-D-202004),Shanghai Talent Development Fund,China(Grant No.:2019093),Shanghai Sailing Program,China(Program No.:22YF1441500),and Three-year Action Plan for Shanghai TCM Development and Inheritance Program,China(Grant No.:ZY(2021-2023)-0401).
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