CRISPR screening redefines therapeutic target identification and drug discovery with precision and scalabilityOA
CRISPR screening redefines therapeutic target identification and drug discovery with precision and scalability
Yao He;Xiao Tu;Yuxin Xue;Yuxuan Chen;Bengui Ye;Xiaojie Li;Dapeng Li;Zhihui Zhong;Qixing Zhong
Laboratory of Neurological Disease Modeling and Translational Research,West China Hospital,Sichuan University,Chengdu,610041,ChinaLaboratory of Neurological Disease Modeling and Translational Research,West China Hospital,Sichuan University,Chengdu,610041,China||Medical Innovation Center,Sichuan University of Science & Engineering,Zigong,Sichuan,643002,ChinaLaboratory of Neurological Disease Modeling and Translational Research,West China Hospital,Sichuan University,Chengdu,610041,ChinaKey Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu,610041,ChinaKey Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu,610041,China||Medical College of Tibet University,Lasa,850002,ChinaLaboratory of Neurological Disease Modeling and Translational Research,West China Hospital,Sichuan University,Chengdu,610041,ChinaKey Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu,610041,ChinaLaboratory of Neurological Disease Modeling and Translational Research,West China Hospital,Sichuan University,Chengdu,610041,ChinaLaboratory of Neurological Disease Modeling and Translational Research,West China Hospital,Sichuan University,Chengdu,610041,China||Tianfu Jincheng Laboratory,City of Future Medicine,Chengdu,641400,China
CRISPR-CasGene editingTargets identificationDrug discovery
CRISPR-CasGene editingTargets identificationDrug discovery
《药物分析学报（英文）》 2026 (2)
359-376,18
This project was supported by National Natural Science Foun-dation of China(Grant No.:82071349),Sichuan Science and Technology Program,China(Grant No.:2025ZNSFSC0703),Young Scientists Fund of the National Natural Science Foundation of China(Grant No.:82204513),Natural Science Foundation of Sichuan Province,China(Grant No.:2023NSFSC1673),Innovation Guidance Foundation of the Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,China(Grant No.:SCU2023D005),and Scientific Research Staring Foundation of Sichuan University,China(Grant No.:YJ202165).The authors would like to thank Sichuan Junhui Biotechnology Co.,Ltd.and Singapore HumanSim Pte.Ltd.for helping this study.
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