基于"生病起于过用"理论探讨代谢相关脂肪性肝病的发病机制OA
Discussion on the Pathogenesis of Metabolic Associated Fatty Liver Disease:Based on the Theory of"Illness Originates from Overuse"
代谢相关脂肪性肝病(MAFLD)是全球最常见的慢性肝病,其发病率持续攀升,发病机制较为复杂,国内目前缺乏相关特效治疗药物上市.基于《黄帝内经》"生病起于过用"理论,对 MAFLD的病机、治法等进行探析,发现 MAFLD的主要病机为本虚标实,表现为肝脾肾虚、痰瘀互结之证,以疏肝健脾、补肾固本,祛痰化湿、化瘀通络为治疗法则.从病机角度探讨"生病起于过用"理论在代谢相关脂肪性肝病治疗中的作用,为 MAFLD的防治提供新的视角.
Metabolic associated fatty liver disease(MAFLD)is the most common chronic liver disease worldwide,with its incidence rate continuously rising.The disease pathology is rather complex,and there are currently no specific thera-peutic drugs available in China.Based on the theory of"illness originates from overuse"in the Huangdi Neijing,the pathogenesis and treatment methods of MAFLD are explored.It is found that the main pathogenesis of MAFLD is characterized by deficiency at the root and excess at the surface,manifested as deficiency of the liver,spleen and kidney,and the interconnection of phlegm and blood stasis.The treatment principle is to soothe the liver,strengthen the spleen,tonify the kidney and consolidate the root,eliminate phlegm and dampness,and remove blood stasis to unblock the meridians.This paper discusses the role of the theory of"illness originates from overuse"in the treatment of MAFLD from the perspective of pathogenesis,providing a new perspective for the prevention and treatment of MAFLD.
宋思妤;史晓伟
甘肃中医药大学 中医临床学院,甘肃 兰州 730000甘肃省中医院,甘肃 兰州 730000
医药卫生
代谢相关脂肪性肝病肝脾肾虚痰瘀互结生病起于过用发病机制
metabolic associated fatty liver diseasedeficiency of liver,spleen and kidneyinterconnection of phlegm and blood stasisillness arises from overusepathogenesis
《亚太传统医药》 2026 (6)
189-193,5
国家自然科学基金项目(82360884,82360955)甘肃省中医药管理局中医药防治重大疾病科研项目(GZKZ-2024-6)
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