基于超声多模态成像技术评估慢性肾病分期的临床研究OA

Objective To explore the application value of ultrasound multimodal imaging technology in the clinical staging assessment of chronic kidney disease(CKD).Methods A total of 90 patients with type 2 diabetic nephropathy-induced CKD(staged from G1 to G5)admitted to Nanjing Gaochun People's Hospital from January 2023 to December 2025 were selected as the study group,and another 30 healthy subjects were selected as the control group.All subjects underwent routine two-dimensional and color Doppler ultrasound,real-time shear wave elastography(SWE),and contrast-enhanced ultrasound(CEUS)examinations to measure relevant ultrasound parameters and explore the correlations and evaluation efficacy of each parameter with CKD staging.Results As CKD staging progressed,the peak systolic velocity(PSV)of the renal aorta,segmental artery,and interlobular artery gradually decreased,while the resistance index(RI)gradually increased;the Young's modulus value of the renal parenchyma and the time to peak(TTP)of CEUS gradually increased,while the ascending slope(A)and peak intensity(PI)of CEUS gradually decreased,with statistically significant differences between groups(P<0.05).Correlation analysis showed that the Young's modulus value of the renal parenchyma,RI of the interlobular artery,and PI had the highest correlation with CKD staging(allrabsolute values>0.7).Receiver operating characteristic(ROC)curve analysis revealed that the area under the curve(AUC=0.918)for the combined detection of these three parameters in evaluating CKD staging was higher than that for a single parameter,with the sensitivity and specificity reaching 94.17%and 93.33%,respectively.Conclusions Ultrasound multimodal imaging technology can reflect the renal parenchyma structure,blood perfusion,and fibrosis degree in CKD patients,and each parameter is closely related to CKD staging.Combined detection can significantly improve the evaluation efficacy of CKD staging.