滋阴养血和解汤治疗阴虚湿热型干眼症临床研究OA
Clinical Study on Ziyin Yangxue Hejie Decoction for Dry Eye Syndrome of Yin Deficiency and Damp-Heat Type
目的:观察滋阴养血和解汤治疗阴虚湿热型干眼症的疗效及对泪液中成纤维细胞生长因子受体(FGFR2)及泪膜破裂时间(BUT)的影响.方法:选取2023年10月—2025年8月平顶山市第二人民医院眼科收治的干眼症患者126例(252眼),按随机数字表法分为对照组和观察组各63例(126眼).对照组给予常规滴眼用药治疗,观察组在对照组基础上加用滋阴养血和解汤治疗,连续治疗1个月.评价2组临床疗效,比较 2 组中医证候评分、泪液相关指标、FGFR2,统计不良反应发生率.结果:观察组总有效率为95.24%(60/63),高于对照组82.54%(52/63)(P＜0.05).治疗后,2组各项中医证候评分较治疗前降低(P＜0.05),且观察组各项中医证候评分低于对照组(P＜0.05).治疗后,2组泪膜破裂时间(BUT)、泪液分泌试验(SIt)值、FGFR2较治疗前升高,角膜荧光素染色(FL)评分较治疗前降低(P＜0.05);且观察组BUT、SIt值、FGFR2高于对照组,FL评分低于对照组(P＜0.05).2组不良反应发生率比较,差异无统计学意义(P＞0.05).结论:滋阴养血和解汤治疗阴虚湿热型干眼症的临床效果显著,可改善患者临床症状和泪液相关指标,提高FGFR2水平,安全性高.
Objective:To observe the efficacy of Ziyin Yangxue Hejie Decoction in treating dry eye syndrome of yin deficiency and damp-heat type,and to explore its effects on fibroblast growth factor receptor 2(FGFR2)in tears and tear film break-up time(BUT).Methods:A total of 126 patients(252 eyes)with dry eye syndrome admitted to the Department of Ophthalmology of Pingdingshan The Second People's Hospital from October 2023 to August 2025 were selected and randomly divided into a control group and an observation group using a random number table method,with 63 cases(126 eyes)in each group.The control group received routine eye drop treatment,while the observation group received additional Ziyin Yangxue Hejie Decoction based on the control group's treatment.Both groups were treated for one consecutive month.Clinical efficacy was evaluated,and traditional Chinese medicine syndrome scores,tear-related indicators,and FGFR2 levels were compared between the two groups.The incidence of adverse reactions was also recorded.Results:The total effective rate was 95.24%(60/63)in the observation group,higher than that of 82.54%(52/63)in the control group(P＜0.05).After treatment,traditional Chinese medicine syndrome scores decreased in both groups compared to before treatment(P＜0.05),and the observation group had lower scores than the control group(P＜0.05).After treatment,tear film BUT,Schirmer Ⅰ test(S Ⅰ t)values,and FGFR2 levels increased in both groups compared to before treatment,while corneal fluorescein staining(FL)scores decreased(P＜0.05).The observation group showed higher BUT,S Ⅰ t values,and FGFR2 levels,and lower FL scores than the control group(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Ziyin Yangxue Hejie Decoction demonstrates significant clinical efficacy in treating dry eye syndrome of yin deficiency and damp-heat type.It improves clinical symptoms and tear-related indicators,increases FGFR2 levels,and exhibits a high safety profile.
原少佳
平顶山市第二人民医院宝丰分院五官科,河南 平顶山 467400
医药卫生
干眼症阴虚湿热型滋阴养血和解汤成纤维细胞生长因子受体泪膜破裂时间
Dry eye syndromeYin deficiency and damp-heat typeZiyin Yangxue Hejie DecoctionFibroblast growth factor receptor 2Tear film break-up time
《新中医》 2026 (11)
35-39,5
评论