补肾活血壮骨汤联合西药治疗绝经后骨质疏松症肾虚血瘀证临床研究OA

Objective:To observe the curative effect of Bushen Huoxue Zhuanggu Decoction combined with western medicine on postmenopausal osteoporosis with kidney deficiency and blood stasis syndrome.Methods:A total of 98 patients with postmenopausal osteoporosis with kidney deficiency and blood stasis syndrome diagnosed and treated in Wenzhou TCM Hospital of Zhejiang Chinese Medical University from January 2024 to April 2025 were included in the study.According to the random number table method,they were divided into the trial group and the control group,with 49 cases in each group.Both groups were treated with Calcium Carbonate and Vitamin D3 Tablets and Denosumab Injection,and the trial group was additionally treated with Bushen Huoxue Zhuanggu Decoction.Both groups were treated for three months.Bone turnover markers[carboxy-terminal peptide of type Ⅰ procollagen(β-CTX),total type Ⅰ procollagen N-terminal propeptide(tP1NP),osteocalcin(OC)]were detected before and after treatment in the two groups.The degree of bone pain[Visual Analogue Scale(VAS)scores]and traditional Chinese medicine syndrome scores were evaluated.The total effective rate and the incidence of adverse reactions were compared between the two groups.Results:After three months of treatment,the total effective rate was 91.84%(45/49)in the trial group and 77.55%(38/49)in the control group,the difference being significant(P＜0.05).The concentrations of serum β-CTX and tP1NP in the two groups were decreased when compared with those before treatment,and the concentrations of OC was increased when compared with that before treatment,differences being significant(P＜0.05);the concentrations of serum β-CTX and tP1NP in the trial group were lower than those in the control group,and the OC concentration was higher than that in the control group,differences being significant(P＜0.05).The VAS scores in the two groups were decreased when compared with those before treatment,and the VAS score in the trial group was lower than that in the control group,differences being significant(P＜0.05).The traditional Chinese medicine syndrome scores in the two groups were reduced when compared with those before treatment,and the traditional Chinese medicine syndrome scores in the trial group were lower than those in the control group,differences being significant(P＜0.05).During treatment,the incidence of adverse reactions was 16.33%(8/49)in the trial group and 10.20%(5/49)in the control group,there being no significance in the difference between the two groups(P＞0.05).Conclusion:Bushen Huoxue Zhuanggu Decoction combined with western medicine can improve the curative effect on postmeopausal osteoporosis with kidney deficiency and blood stasis syndrome,which can effectively improve the relevant traditional Chinese medicine syndromes,relieve osteoporotic bone pain,and improve bone metabolic imbalance with good safety.