肠道微生物组与宿主DNA甲基化互作对动物生长发育及健康的影响研究进展OA

Animal gut microbiome is a complex ecosystem composed of bacteria,fungi,protozoa,bacteriophages,and other microorganisms.Through synergistic interactions,it maintains intestinal microecological balance and deeply participates in host physiological regulation,immune responses,and metabolic functions.Dysbiosis of gut microbiota not only restricts host growth and development,causes immune disorders,and metabolic diseases but also interacts with host genomes via microbial metabolites to affect epigenetic modifications(e.g.,DNA methylation),thereby exerting profound impacts on host health.As a key epigenetic mechanism,DNA methylation shapes host physiological phenotypes by regulating gene expression and maintaining genomic stability.However,the collaborative mechanisms between DNA methylation and gut microbiota remain unclear.This paper reviews the interaction patterns between gut microbiome and DNA methylation,focusing on the regulatory pathways of microbial metabolites on host methylation modifications and the potential mechanisms by which they jointly influence animal health,growth and development,and production performance.Aiming to provide a theoretical basis and research perspective for optimizing animal production performance and regulating host health,and to promote the application of research on gut microbiota-epigenetic interactions in the livestock sector.