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医学长文本因果证据链识别的分阶段微调方法研究OACHSSCD

Two-Stage Fine-Tuning Method for Causal Evidence Chain Identification in Long-Form Medical Texts

中文摘要英文摘要

[目的/意义]在"健康中国"战略背景下,医学长文本细粒度知识与因果证据链的自动识别是医学情报挖掘的关键.[方法/过程]针对医学长文本结构复杂、因果关系强度难识别等问题,本文提出分阶段微调的识别方法.以PubMed Central数据库为语料来源,筛选101篇高复杂度医学长文本,构建含8 005个标签实例的标注语料库,建立L1实体、L2属性修饰、L3因果证据链三层标注体系.以Qwen3-8B为基座,结合低秩适配高效微调与显存优化,采用两阶段渐进式微调策略,先联合抽取实体与属性,再判定因果强度并定位证据.[结果/结论]实验表明,模型在L1层药物实体识别F1值83.89%,L1层不良反应实体识别F1值59.45%,L2层属性识别F1值51.12%,L3层因果分类Macro-F1达75.05%,证据跨度精确匹配率58.75%,均优于基线模型.该方法实现了细粒度知识与因果证据链的协同识别,为医学情报自动化加工提供了技术路径.

[Purpose/Significance]Under the background of the Healthy China strategy,the automatic identification of fine-grained knowledge elements and causal evidence chains in long-form medical texts is a key issue in medical infor-mation mining.[Method/Process]To address problems such as the complex structure of medical long texts and the diffi-culty in distinguishing the strength of causal relationships,this study proposed a recognition method based on two-stage fine-tuning.Medical literature from the PubMed Central(PMC)database was used as the data source.After screening,101 high-complexity medical long texts were selected to construct an annotated corpus containing 8005 labeled instances.A three-level annotation framework was established,including L1 entities,L2 attribute modifiers,and L3 causal evidence chains.Based on the Qwen3-8B architecture,the model was trained using parameter-efficient fine-tuning with LoRA and memory optimization techniques.A two-stage progressive fine-tuning strategy was adopted,in which entities and attri-butes were jointly extracted in the first stage,followed by causal strength classification and evidence span localization in the second stage.[Result/Conclusion]Experimental results show that the model achieves an F1 score of 83.89%in L1 drug entity recognition,an F1 score of 59.45%in L1 adverse drug reaction entity recognition,an F1 score of 51.12%in L2 attribute recognition,and a Macro-F1 score of 75.05%in L3 causal classification.The exact match rate for evidence span identification reaches 58.75%,which is superior to the baseline model.The proposed method enables coordinated identification of fine-grained knowledge elements and causal evidence chains,providing a technical approach for auto-mated medical information processing.

袁晓园

南京大学图书馆,江苏 南京 210036

医药卫生

医学长文本细粒度知识抽取因果证据链识别大语言模型微调循证医学

long-form medical textsfine-grained knowledge extractioncausal evidence chain recognitionlarge language model fine-tuningevidence-based medicine

《现代情报》 2026 (6)

76-88,13

江苏省社会科学面上项目"面向预防为主的医疗健康数据知识组织与知识服务平台构建研究"(项目编号22TQB003)江苏省教育厅哲学社会科学一般项目"基于DIKW转化体系的双一流学科知识抽取服务创新研究"(项目编号:2022JYB0004).

10.3969/j.issn.1008-0821.2026.06.007

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