甲状腺功能障碍与泌尿系结石的因果关系:一项两样本孟德尔随机化研究OA

Objective To explore the causal relationship between thyroid disorders and urolithiasis through Mendelian ran-domization(MR).Methods Data on hyperthyroidism,hypothyroidism,thyroid cancer,thyroid-stimulating hormone(TSH),free thyroxine(FT4),free triiodothyronine/free thyroxine(FT3/FT4),and urolithiasis were collected from large-scale genome-wide associ-ation studies(GWAS).A two-sample MR analysis was conducted.The study included data from individuals of European ancestry.Causal associations between thyroid disorders and urolithiasis were assessed using inverse variance weighting(IVW),MR-Egger re-gression,weighted median,and weighted mode methods.Cochran's test was used to evaluate heterogeneity,and the MR-Egger inter-cept test was applied to assess horizontal pleiotropy.The MR-PRESSO method was employed to detect and correct potential outlier in-strumental variables.Results The IVW method showed a negative causal relationship between hypothyroidism and urolithiasis,indica-ting that hypothyroidism could reduce the risk of urolithiasis(OR=0.939,95%CI=0.8823-0.9993,P=0.047).No causal associations were observed between hyperthyroidism,thyroid cancer,serum TSH,FT4,FT3/FT4 and the risk of urolithiasis.No significant heteroge-neity or horizontal pleiotropy was detected.Conclusions There is a potential causal relationship between hypothyroidism and urolithiasis.