气管支气管腺样囊性癌的临床特征及中医证候研究OA

[Objective]To explore the clinical and traditional Chinese medicine(TCM)syndrome characteristics of patients with tracheobronchial adenoid cystic carcinoma(TACC),providing scientific evidence for TCM clinical diagnosis and treatment of TACC.[Methods]A dual-center cross-sectional study was conducted to collect clinical and TCM syndrome data from 112 TACC patients.Statistical analysis included factor analysis,multiple correspondence analysis,K-means clustering,hierarchical clustering,and latent class analysis using R software to cluster and mine the structure of syndrome entries.Topological network analysis was employed to identify core syndrome variables,and latent class analysis validated syndrome classification rationality.[Results]A total of 112 TACC patients were enrolled from two centers,with a higher prevalence in females than in males.The lesions predominantly involved the middle and lower segments of the major airways.No significant sex differences were observed in clinical characteristics such as the primary tumor site,patterns of infiltration,or metastatic status.The most common TCM syndrome manifestations included cough(84.82%),dyspnea(59.82%),viscous sputum(46.43%),and spontaneous sweating(45.54%).The most frequent tongue and pulse features were white tongue coating(72.32%),stagnated tongue vessels(49.11%),slippery pulse(36.61%),and rapid pulse(33.93%).Through factor analysis,cluster analysis,and latent class analysis,three major TCM syndrome patterns of TACC were identified.[Conclusion]The pathogenesis of TACC is characterized by a complex interplay of deficiency and excess,with a protracted disease course consistently complicated by cancer toxin.The three predominant TCM syndrome patterns were summarized as follows:1)Qi deficiency with fluid depletion accompanied by phlegm-heat obstructing the collaterals;2)Lung-spleen deficiency with damp-turbidity stagnating the collaterals;3)Blood stasis and toxin accumulation with collateral damage leading to hemorrhage.