1990-2021年中国归因于高体质量指数的肿瘤疾病负担分析OA

Objective To investigate the disease burden of neoplasms attributable to high body mass index(BMI)in the Chinese popula-tion,compare it with global data and data from the United States and Japan,and analyze the trend of mortality in China across age,period,and cohort factors.Methods Based on the Global Burden of Disease Study 2021(GBD 2021)database,this study focused on Chinese residents aged≥20 years from 1990 to 2021.Metrics including the number of deaths,age-standardized mortality rate(ASMR),disabil-ity-adjusted life years(DALYs),years lived with disability(YLDs),and years of life lost(YLLs)attributable to high BMI were extracted.Corresponding global data and national data of the United States and Japan were also collected for comparison.The age-period-cohort(APC)model was employed to estimate the age,period,and cohort effects on high BMI-attributable neoplasm mortality in China,using Stata SE 16.0 software and the intrinsic estimator algorithm for analysis.Results From 1990 to 2021,the disease burden of neoplasms attributable to high BMI in China exhibited a significant upward trajectory,consistent with the trends observed globally and in the United States and Ja-pan.The number of deaths in Chinese neoplasm patients due to high BMI rose from 11 556.2 in 1990 to 58 745.2 in 2021.ASMR increased from 1.36/100 000 in 1990 to 2.81/100 000 in 2021,representing a growth of 106.62%,which was markedly higher than those of the world(14.13%),the United States(7.14%),and Japan(7.44%).The APC model analysis showed that from 1990 to 2021,the age and period ef-fects on high BMI-attributable neoplasm mortality in the Chinese population followed a gradual upward trend,while the cohort effect ex-hibited a downward trend.Sex-and age-specific analyses revealed that deaths,DALYs,YLLs,and YLDs continued to grow for both males and females from 1990 to 2021.High BMI-attributable mortality rates increased with age and consistently peaked in the age group of≥80 years across all periods.Conclusions The disease burden of neoplasms attributable to high BMI in China from 1990 to 2021 is increasing,and has become a public health problem.The government and all sectors of society should strengthen awareness and publicity about obe-sity,and guide people to adopt healthy lifestyles and eating habits through health education activities.Interventions should be targeted at people of different genders and ages.