2012-2024年上海市虹口区丙型肝炎患者死因分析OA

[Objective]To systematically analyze the epidemiological characteristics and cause-of-death distribution among death cases with hepatitis C in Hongkou District of Shanghai,and to provide a scientific basis for optimizing healthcare resources allocation and targeted hepatitis C prevention and control measures.[Methods]A retrospective cross-sectional study was conducted by integrating historical surveillance data from China Information System of Disease Prevention and Control and Shanghai Hongkou District Death Medical Registration System.Data on demographic characteristics,hepatitis C-related clinical and management records,and underlying causes of death for cases with hepatitis C between 2012 and 2024 in Hongkou District of Shanghai,were collected.Descriptive analyses were performed to analyze the epidemiological characteristics and cause-of-death distribution of death cases,and comparative analyses were conducted across different subgroups.[Results]A total of 204 hepatitis C-related deaths were identified in Hongkou District,Shanghai,from 2012 to 2024.The average age at death was(69.49±12.75)years The majority decedents were males(71.57%)and retired(73.53%).The top three underlying causes of death were malignant tumors(45.10%),cerebrovascular diseases(15.20%)and cardiovascular diseases(12.25%),collectively accounting for 72.55%of all deaths.Deaths attributed to hepatitis C accounted for 9.80%(20/204),with a mean age at death of(63.41±11.81)years.No statistically significant differences were observed in the proportion of hepatitis C-attributed deaths across different subgroups(all P>0.05).The proportion of premature deaths was 55.88%(114/204),with a mean age at death of(60.02±6.89)years.The proportion of premature deaths was higher among males(60.27%),laboratory-diagnosed patients(62.69%),patients with other liver diseases(72.06%),and those non-compliant with follow-up(70.97%)compared to their respective counterparts(all P<0.05).Additionally,homemakers/unemployed patients(100.00%)and employed patients(88.89%)had a significantly higher proportion of premature deaths compared to retired patients(42.67%)(P<0.001).There was a statistically significant difference in the distribution of causes of death between the premature death group and the non-premature death group(χ2=14.93,P=0.048).The top three causes of premature deaths were malignant tumors(50.00%),hepatitis C(12.28%)and cerebrovascular diseases(10.53%).Regarding the proportion of deaths occuring prematurely,other viral hepatitis had the highest percentage(75.00%),followed by diabetes mellitus(71.43%)and hepatitis C(70.00%).[Conclusion]The majority of death cases with hepatitis C were males and retirees in Hongkou District,Shanghai.The leading cause of death was malignant tumors,while hepatitis C ranked as the fourth underlying cause,as well as served as the second leading cause of premature death following malignant tumors.Premature death was closely associated with gender,occupation,diagnostic classification,presence of other liver diseases,and follow-up compliance,highlighting the importance of enhanced health management and targeted interventions among high-risk groups.