中国东部监狱羁押人群结核潜伏感染的流行病学特征及影响因素OA
Epidemiological characteristics and influencing factors of latent tuberculosis infection among detainees in eastern China
[目的]分析中国东部地区新进羁押人群结核潜伏感染(LTBI)的流行病学特征,识别高危人群,为制定监狱系统结核病防控策略提供科学依据.[方法]采用横断面研究设计,以2022年中国东部2所监狱新进羁押人群为研究对象.通过结构化问卷收集研究对象的人口学特征、行为危险因素、既往疾病史等信息,采用QuantiFERON-TB Gold In-Tube(QFT-GIT)检测羁押人群LTBI状况.用Lasso回归分析筛选变量,用多因素logistic回归分析研究LTBI的影响因素.[结果]共纳入305名研究对象.研究对象的年龄中位数为35(31,43)岁,研究对象以男性(67.21%)、汉族(95.41%)、初高中文化程度(59.34%)、无业者(31.80%)为主.研究对象大多曾吸烟(52.79%),无饮酒史(57.70%),无高血压(85.90%)、糖尿病(93.77%)、人类免疫缺陷病毒(HIV)感染(97.38%)、家族遗传病(95.08%)、手术外伤史(73.77%)、吸毒史(92.79%)、肝炎患病史(93.77%).LTBI率为14.75%.对比LTBI与非感染者组的人口学特征后发现,吸烟史(χ2=7.40,P=0.025)、吸毒史(χ2=5.49,P=0.019)及人类免疫缺陷病毒(HIV)感染(χ2=8.12,P=0.004)与LTBI感染存在关联.多因素logistic回归分析结果显示,曾吸烟[调整比值比(a OR)=4.08,95%CI:1.60～10.42,P=0.003],感染 HIV(aOR=11.57,95%CI:2.50～53.51,P=0.002),有吸毒史(a OR=3.04,95%CI:1.02～9.09,P=0.046)与LTBI正相关.[结论]中国东部地区2所监狱的新进羁押人群的LTBI率略低于长期羁押人群,工作中应对新进羁押人员开展早期筛查与干预,重点关注曾吸烟、感染HIV、有吸毒史的高危人群.
[Objective]To analyze the epidemiological characteristics of latent tuberculosis infection(LTBI)among newly detained populations in eastern China,to identify high-risk groups,and to provide a scientific basis for formulating tuberculosis prevention and control strategies in the prison system.[Methods]A cross-sectional study was conducted among the newly admitted detainees in two prisons in eastern China in 2022.Data on demographic characteristics,behavioral risk factors and previous disease history of the research subjects were collected through a structured questionnaire survey.The LTBI status of the detainees was determined using the QuantiFERON-TB Gold In-Tube(QFT-GIT)method.Lasso regression was used to screen variables,followed by multivariate logistic regression analysis to investigate the influencing factors of LTBI.[Results]A total of 305 detainees were included in the study.The median age of detainees was 35(31,43)years.The study population was predominantly male(67.21%),of Han ethnicity(95.41%),had a junior or senior high school education(59.34%),and was unemployed(31.80%).A history of smoking was reported by 52.79%of participants,while 57.70%reported no alcohol consumption.The majority had no history of hypertension(85.90%),diabetes mellitus(93.77%),human immunodeficiency virus(HIV)infection(97.38%),familial genetic diseases(95.08%),surgery or trauma(73.77%),drug use(92.79%),or hepatitis(93.77%).The LTBI rate was 14.75%.After comparing the demographic characteristics of LTBI and non-infected groups,it was found that smoking history(χ2=7.40,P=0.025),drug use history(χ2=5.49,P=0.019),and HIV infection(χ2=8.12,P=0.004)were statistically correlated with LTBI infection.The results of multivariate logistic regression analyses showed that smoking[adjusted odds ratio(aOR)=4.08,95%CI:1.60-10.42,P=0.003],HIV infection(aOR=11.57,95%CI:2.50-53.51,P=0.002)and drug use(aOR=3.04,95%CI:1.02-9.09,P=0.046)were risk factors for LTBI.[Conclusion]The LTBI rate among newly detainees in two prisons in eastern China is slightly lower than that among long-term detainees.Early screening and intervention should be implemented for newly detainees,with particular attention focused on high-risk groups such as those with a history of smoking,HIV infection,or drug use.
费心如;卢鹏;宁静娴;潘昱辰;竺丽梅;刘巧;周红喜
江苏省疾病预防控制中心慢性传染病防制所,江苏 南京 210009江苏省疾病预防控制中心慢性传染病防制所,江苏 南京 210009江苏省疾病预防控制中心慢性传染病防制所,江苏 南京 210009江苏省疾病预防控制中心慢性传染病防制所,江苏 南京 210009江苏省疾病预防控制中心慢性传染病防制所,江苏 南京 210009江苏省疾病预防控制中心慢性传染病防制所,江苏 南京 210009江苏省监狱管理局中心医院,江苏 常州 213300
医药卫生
结核分枝杆菌结核潜伏感染监狱羁押人群影响因素
Mycobacterium tuberculosislatent tuberculosis infectionprisondetained populationinfluencing factor
《上海预防医学》 2026 (4)
280-283,4
国家自然科学基金项目(82003516)江苏省卫生健康委员会科研面上项目(M2020020)
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