hUMSC-derived exosomes alleviate hypoxic cerebrovascular injury via AMPK/NLRP 3-mediated pyroptosis suppression and mitochondrial protectionOA
hUMSC-derived exosomes alleviate hypoxic cerebrovascular injury via AMPK/NLRP 3-mediated pyroptosis suppression and mitochondrial protection
Jinteng Liu;Yunlong Pan;Haolin Wu;Qingyun Guo;Xingyue Fang;Yingmei Lu;Qibing Liu
Department of Pharmacy&Engineering Research Center of Tropical Medicine Innovation and Transformation,the First Affiliated Hospital&School of Pharmacy of Hainan Medical University,Haikou,Hainan 570102,ChinaKey Laboratory of Modern Toxicology of Ministry of Education||School of Basic Medical Sciences,Nanjing Medical University,Nanjing,Jiangsu 211166,ChinaInternational Research Center on Aging and Tumor,Hainan Medical University,Haikou,Hainan 571199,ChinaKey Laboratory of Brain Science Research&Transformation in Tropical Environment of Hainan Province,Hainan Medical University,Haikou,Hainan 571199,ChinaDepartment of Pharmacy&Engineering Research Center of Tropical Medicine Innovation and Transformation,the First Affiliated Hospital&School of Pharmacy of Hainan Medical University,Haikou,Hainan 570102,ChinaKey Laboratory of Modern Toxicology of Ministry of Education||School of Basic Medical Sciences,Nanjing Medical University,Nanjing,Jiangsu 211166,ChinaDepartment of Pharmacy&Engineering Research Center of Tropical Medicine Innovation and Transformation,the First Affiliated Hospital&School of Pharmacy of Hainan Medical University,Haikou,Hainan 570102,China
医药卫生
strokehUMSC-ExosAMPK/NLRP3 signaling pathwaypyroptosissynergistic combination therapy
strokehUMSC-ExosAMPK/NLRP3 signaling pathwaypyroptosissynergistic combination therapy
《生物医学研究杂志（英文版）》 2026 (3)
312-326,15
This work was supported by the National Key Research and Development Program of China(Grant No.2022YFE0108600 to Y.M.L.),the National Natural Science Foundation of China(Grant Nos.82460709 and 81960663 to Q.B.L.),the Key Project of Hainan Provincial Department of Education(Grant No.Hnky2019ZD-25 to Q.B.L.),and the Hainan Province High-level Talent Project(Grant No.2019RC228 to Q.B.L.).
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