阿替普酶静脉溶栓联合尤瑞克林对急性缺血性脑卒中患者血清BDNF、NSE水平及预后的影响OA

Aim To analyze the effects of intravenous thrombolysis with alteplase combined with urinary kallidinogenase on levels of serum brain-derived neurotrophic factor(BDNF)and neuron-specific enolase(NSE)and prognosis in patients with acute is-chemic stroke(AIS).Methods A total of 160 AIS patients who received intravenous thrombolysis with alteplase combined with urinary kallidinogenase were selected as the study subjects,and were divided into a good prognosis group and a poor prognosis group based on their prognosis.The clinical data and levels of BDNF and NSE were compared between the two groups.Multiple Logistic regression analysis was adopted to investigate the influencing factors of the prognosis in AIS patients.ROC curve was used to evaluate the predictive value of serum BDNF and NSE for AIS prognosis.Results The age,proportion of patients with hypertension,Na-tional Institutes of Health Stroke Scale(NIHSS)score at admission,Modified Rankin Scale score at 14 days post-discharge and serum NSE levels in the poor prognosis group were higher than those in the good prognosis group,while serum BDNF levels were lower than those in the good prognosis group(P<0.05).The results of multiple Logistic regression analysis showed that NIHSS score>12.34 at admission,serum BDNF≤10.45 μg/L,and serum NSE>10.23 μg/L,merged hypertension were risk factors for poor prognosis in AIS(P<0.05).Serum BDNF and NSE showed high predictive value for the prognosis of AIS,and the combined detection was better than a single indicator.Conclusion The combination of alteplase intravenous thrombolysis and urinary kallidinogenase can signif-icantly increase the serum BDNF level and reduce the NSE level in AIS patients,and the predictive value of the combined detection is higher than that of a single indicator.