基于厥阴理论应用龙胆泻肝汤加味治疗肝胆湿热证玫瑰痤疮患者的临床效果OA
Clinical efficacy of modified Longdan Xiegan decoction based on Jueyin theory in the treatment of rosacea patients with hepatobiliary damp-heat syndrome
目的 观察基于厥阴理论应用龙胆泻肝汤加味治疗肝胆湿热证玫瑰痤疮的临床效果.方法 选取2023年9月—2025年5月长春中医药大学附属医院收治的60例肝胆湿热证玫瑰痤疮患者,按随机数字表法分为两组,各30例.对照组予以西医常规治疗,观察组在此基础上予以龙胆泻肝汤加味,两组均治疗6周.比较两组临床疗效、临床症状评分、白细胞介素-8(IL-8)、Toll样受体2(TLR2)、肿瘤坏死因子-α(TNF-α)、皮肤病生活质量指数(DLQI)评分及不良反应发生情况.结果 观察组总有效率为96.67%(29/30),高于对照组的73.33%(22/30,P<0.05).治疗3、6周后,观察组红斑、瘙痒、毛细血管扩张评分以及血清IL-8、TNF-α、TLR2均低于对照组,丘疹脓疱数少于对照组(P<0.05).治疗6周后,观察组DLQI评分分布情况较对照组更优(P<0.05).两组不良反应发生率比较差异无统计学意义(P>0.05).结论 基于厥阴理论应用龙胆泻肝汤加味治疗肝胆湿热证玫瑰痤疮患者可有效降低炎症因子水平,缓解临床症状,改善生活质量,且安全性较好.
Objective To observe the clinical efficacy of modified Longdan Xiegan decoction based on Jueyin theory in the treatment of rosacea with hepatobiliary damp-heat syndrome.Methods A total of 60 rosacea patients with hepatobiliary damp-heat syndrome admitted to the Affiliated Hospital of Changchun University of Traditional Chinese Medicine from September 2023 to May 2025 were selected,and divided into two groups by random number table method,with 30 patients in each group.The control group received conventional Western medicine treatment,while the observation group was supplemented with modified Longdan Xiegan decoction on the basis of the control group.Both groups were treated for 6 weeks.The clinical efficacy,clinical symptom scores,levels of interleukin-8(IL-8),Toll-like receptor 2(TLR2),and tumor necrosis factor-α(TNF-α),Dermatology Life Quality Index(DLQI)score and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 96.67%(29/30),which was higher than 73.33%(22/30)of the control group(P<0.05).At 3 and 6 weeks after treatment,the scores of erythema,pruritus,telangiectasia,and serum levels of IL-8,TNF-α and TLR2 in the observation group were lower than those in the control group,and the number of papules and pustules was less than that in the control group(P<0.05).At 6 weeks after treatment,the DLQI score of the observation group was better than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of modified Longdan Xiegan decoction based on Jueyin theory in the treatment of rosacea with hepatobiliary damp-heat syndrome can effectively reduce the levels of inflammatory factors,relieve clinical symptoms and improve quality of life with good safety.
彭佳雨;景瑛;王毅龙;李之赫;隋龙飞;张莲
长春中医药大学附属医院皮肤科,长春 130000长春中医药大学附属医院皮肤科,长春 130000天津中医药大学中药学院,天津 300000长春中医药大学中医学院,长春 130000长春中医药大学中医学院,长春 130000长春中医药大学附属医院皮肤科,长春 130000
玫瑰痤疮厥阴龙胆泻肝汤肝胆湿热证炎症生活质量不良反应
rosaceaJueyinLongdan Xiegan decoctionhepatobiliary damp-heat syndromeinflammationquality of lifeadverse reaction
《临床误诊误治》 2026 (11)
90-96,7
2024年度吉林省中医药科技项目(2024233)
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