机化性肺炎的临床特点及误诊原因分析OA

Objective To investigate the clinical features,causes of misdiagnosis,and preventive strategies of organizing pneumonia(OP).Methods The clinical data of seven patients with pathologically confirmed OP,who were initially misdiagnosed as pulmonary infection at the First Hospital of Tsinghua University from September 2020 to February 2026,were retrospectively analyzed.Results The predominant clinical manifestations included fever,cough,sputum production,and wheezing.All patients were initially diagnosed with pulmonary infection based on clinical symptoms,laboratory tests,and chest imaging,but showed unsatisfactory responses to empirical antimicrobial therapy.Definite diagnoses of OP were subsequently established via bronchoscopic alveolar lavage,transbronchial lung biopsy,or percutaneous lung puncture biopsy.The misdiagnosis duration ranged from 1 week to 4 months.After initiation of glucocorticoid therapy,all patients achieved clinical remission with favorable outcomes during follow-up.Conclusion OP is frequently misdiagnosed owing to its atypical and heterogeneous early presentations.Enhanced clinical vigilance,detailed history taking,targeted laboratory evaluation,and appropriate invasive examinations are essential to reduce or avoid misdiagnosis.