单细胞(核)转录组测序在衰老研究中的应用OA
Application of single-cell and single-nucleus RNA sequencing in aging research
机体衰老是一个涉及多器官、多维度的复杂生物学过程.单细胞(核)转录组学凭借其单细胞尺度的高分辨率,有助于深入理解衰老的细胞与分子机制,并有望为识别衰老生物标志物及相关疾病靶点提供新视角.现综述单细胞(核)转录组测序技术在衰老生物标志物研究、抗衰老策略与药物筛选及在衰老相关疾病病理机制解析中的研究现状,并讨论其转化研究潜力和未来应用价值.
Aging is a complex biological process that involves multiple organs and dimensions.Owing to its high resolution,single-cell(nucleus)transcriptomics enables in-depth exploration of the cellular and molecular mechanisms underlying aging and the identification of aging biomarkers and therapeutic targets for relevant diseases.This review discusses the advantages of single-cell(nucleus)transcriptomic sequencing technologies in the study of aging biomarkers,summarizes their applications in elucidating anti-aging strategies and screening anti-aging compounds,and highlights their value in uncovering the pathological mechanisms of aging-related diseases.
刘梦杰;訾晓渊;王琛
中国药科大学生命科学与技术学院,南京 210009江苏省单细胞测序工程技术研究中心,南京市高通量单细胞测序工程技术研究中心,南京 210016中国药科大学生命科学与技术学院,南京 210009
医药卫生
单细胞转录组测序单细胞核转录组测序单细胞转录组衰老生物标志物
single-cell RNA sequencingsingle-nucleus RNA sequencingsingle-cell transcriptomicsagingbiomarker
《解剖学杂志》 2026 (2)
97-105,9
江苏省工程技术研究中心项目(BM2023469)
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