光疗调控抑郁症的研究进展OA

The number of patients with depression across the country is large,leading to significant loss of social labor and high medical costs,which together impose a substantial public health burden.Against the background of high relapse rates and frequent side effects associated with traditional pharmacological interventions,phototherapy modulation technology stands out due to its precision and non-invasive nature.In this review,we explore the multi-level mechanisms of phototherapy modulation in depression from various research perspectives.We also summarize findings from two physical intervention methods—bright light therapy(BLT)and photobiomodulation(PBM)—regarding their effects on non-seasonal depression and related clinical evidence.Finally,we look ahead to a future closed-loop precise photomedicine paradigm based on biofeedback,addressing issues such as standardization of the dose-response relationship and biosafety assessment.This perspective aims to provide theoretical support for the use of phototherapy modulation in treating depression.