少突胶质细胞在神经病理性疼痛中的作用机制研究进展OA
Research progress on the role and mechanism of oligodendrocytes in neuropathic pain
神经病理性疼痛(NP)是一种由中枢或周围神经系统损伤引发的慢性疼痛疾病.在神经元支持和轴突绝缘中,少突胶质细胞(OL)的作用已得到广泛研究,但其参与疼痛调节的机制研究仍是一个新兴领域.本文从OL凋亡和OL前体细胞异常分化导致髓鞘稳态失衡、OL分泌白细胞介素(IL)-33、IL-24等炎症因子驱动炎症级联反应及OL与其他神经胶质细胞间的相互作用方面,综述OL在NP中作用机制的相关研究进展,探讨潜在的治疗靶点和新疗法,旨在为NP机制研究提供理论参考和新思路,推动相关治疗方法的发展.
Neuropathic pain(NP)is a chronic pain disorder caused by injury to the central or peripheral nervous systems.The role of oligodendrocytes(OLs)in neuronal support and axonal insulation has been extensively studied;however,research on their involvement in pain modulation remains an emerging field.This review summarizes recent progress in understanding the mechanisms by which OLs contribute to NP,focusing on three key aspects:(1)disruption of myelin homeostasis resulting from OL apoptosis and aberrant differentiation of oligodendrocyte precursor cells(OPCs);(2)activation of inflammatory cascades driven by OL-secreted pro-inflammatory cytokines such as interleukin(IL)-33,IL-24);and(3)intercellular crosstalk between OLs and other glial cells.Potential therapeutic targets and novel treatment strategies are also discussed,aiming to provide theoretical insights and new perspectives for research on NP mechanisms and to promote the development of relevant therapeutic approaches.
王兢燕;周建华;任伟东;李梦杰;许光达;樊哲溪;吕志峰
河南中医药大学第一临床医学院,河南 郑州 450000河南中医药大学第一临床医学院,河南 郑州 450000河南中医药大学第一临床医学院,河南 郑州 450000河南中医药大学第一临床医学院,河南 郑州 450000河南中医药大学第一临床医学院,河南 郑州 450000河南中医药大学第一临床医学院,河南 郑州 450000河南中医药大学第一附属医院麻醉科,河南 郑州 450000
医药卫生
少突胶质细胞神经病理性疼痛髓鞘形成炎症
oligodendrocytesneuropathic painmyelinationinflammation
《解放军医学杂志》 2026 (5)
803-810,8
This work was supported by the Zhengzhou City Medical and Health Sector Science and Technology Innovation Guidance Program(2024YLZDJHO71)郑州市医疗卫生领域科技创新指导计划项目(2024YLZDJHO71)
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