电针联合叩刺拔罐治疗带状疱疹后遗神经痛瘀血阻络证疗效观察OA

Objective:To observe the clinical efficacy of electroacupuncture combined with tapping and cupping therapy in the treatment of postherpetic neuralgia(PHN)with blood stasis blocking collaterals syndrome and its effects on substance P(SP),brain-derived neurotrophic factor(BDNF),and tropomyosin receptor kinase B(TrkB)levels in patients.Methods:A total of 90 PHN patients were randomly divided into the control group and the observation group using the random number table method,with 45 cases in each group.The control group received Gabapentin Capsules,while the observation group further received electroacupuncture and tapping-cupping therapy on the basis of the control group.Then clinical efficacy,incidence of adverse reactions,as well as changes in TCM syndrome scores,visual analogue scale(VAS)scores,Pittsburgh sleep quality index(PSQI)scores,36-item Short Form Health Survey(SF-36)scores,serum biomarker levels(SP,BDNF,TrkB),and Th1/Th2 cytokine indexes[interferon-gamma(IFN-γ),interleukin(IL)-2,tumor necrosis factor-alpha(TNF-α),IL-4,IL-6,IL-10,and Th1/Th2 ratio]before and after treatment were compared between the two groups.Results:After treatment,both groups showed significant reductions in TCM syndrome scores,such as stabbing pain,dull com-plexion,restless sleep,dark purple tongue or petechiae),and the above scores in the observation group were lower than those in the con-trol group,with statistically significant differences(P<0.05).After treatment,VAS and PSQI scores decreased,while SF-36 scores in-creased in both groups,statistically significant differences(P<0.05).SP levels decreased,while BDNF and TrkB levels increased in the two groups,with statistically significant differences(P<0.05).IFN-γ,IL-2,TNF-α,and the Th1/Th2 ratio decreased,whereas IL-4 and IL-10 levels increased in the two groups,with statistically significant differences(P<0.05).The effective rate was93.33%in the observation group and 77.78%in the control group respectively,with a statistically significant difference(P<0.05).However,no significant difference was observed in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Electroacu-puncture combined with tapping and cupping therapy for PHN with blood stasis blocking collaterals syndrome can alleviate clinical symptoms,improve sleep quality,and enhance quality of life of patients.The underlying mechanism may involve regulating the BDNF/TrkB axis signaling pathway and restoring Th1/Th2 immune balance.