基于Nrf2信号通路探讨中医药治疗缺血性脑卒中的作用机制OA

Nuclear factor erythroid 2-related factor 2(Nrf2)is an important factor in regulating cellular oxidative stress.In the patho-logical mechanism of ischemic stroke,it plays roles in regulating programmed cell death,antioxidative stress,anti-neuroinflammation,maintaining blood-brain barrier homeostasis,promoting angiogenesis,and facilitating neural regeneration.Monomeric components of traditional Chinese medicine(TCM)such as terpenoids,glycosides,and alkaloids,as well as TCM formulas including Buyang Huanwu Decoction,Huangqi Guizhi Wuwu Decoction,Huazhuo Jiedu Huoxue Tongluo Formula,and Yinao Fuyan Formula,all can treat ischemic stroke by regulating Nrf2-related signaling pathways.Existing studies have the following shortcomings:there is limited research on the promotion of vascular and neural regeneration by TCM;studies mainly focus on monomer mechanisms,while research on formulas is weak;studies on safe dosage and maximum therapeutic dosage of drugs still need deepening;some experimental designs need improve-ment;and the synergistic regulatory mechanisms of Nrf2 through multiple pathways remain to be further studied.In response,future re-search should strengthen studies on TCM formulas and explore the synergistic regulation mechanisms of Nrf2 across multiple pathways,aiming to provide new ideas and methods for the TCM treatment of ischemic stroke.