基于线粒体稳态从"一气周流"论治心肌缺血再灌注损伤OA

The fundamental pathogenesis of myocardial ischemic reperfusion injury(MIRI)is the dysfunction of central Qi transporta-tion,Cold in Water,constrained in Wood and declining in Fire,Phlegm and blood stasis overwhelming Fire,Qi deficiency with blood sta-sis,leading to insufficient Heart Yang,obstruction of the Heart vessels,and loss of nourishment to the Heart.Many drugs can mitigate a series of pathological reactions during MIRI by regulating mitochondrial homeostasis,thereby improving myocardial damage caused by ischemia/reperfusion.Clinically,based on the theory of"Yi Qi Zhou Liu",the treatment principle is to strengthen the Earth to control Water,unblock Yang to resolve Phlegm;support the center to enhance Fire,promote Qi circulation to remove stasis;benefit and lift Qi,regulate Qi to relieve stagnation.By maintaining the central Earth to operate the whole body,nurturing and regulating central Earth to re-store the authority of its pivot in Qi ascending and descending,and harmonizing each part of the body,the flow of Qi,blood as well as Yin and Yang in the Zang and Fu become smooth,leading to coordinated regulation of mitochondrial biogenesis,autophagy,and fission/fusion balance,promoting the restoration of mitochondrial homeostasis and thereby alleviating MIRI.