SHC1在肿瘤中增殖、侵袭和迁移相关机制的研究进展OA
Research progress of mechanisms related to Proliferation,invasion,and migration of SHC1 in tumors
SHC1 适配蛋白(SHC adaptor protein 1,SHC1)在肿瘤生物学过程中扮演关键角色,通过MAPK/ERK和PI3K/AKT/mTOR信号通路,调控肿瘤细胞增殖、迁移和侵袭.诱导上皮-间质转化,调节细胞骨架,影响肿瘤微环境,进而促进肿瘤侵袭和迁移.本文综述了SHC1在多种肿瘤中的作用机制,包括其对信号通路的调控、对细胞过程的介导以及对肿瘤微环境的影响.探讨了针对 SHC1的治疗策略以及SHC1在肿瘤预后评估中的潜力,为肿瘤精准治疗和个体化医疗提供新思路.本研究深入解析SHC1在肿瘤增殖、迁移和侵袭的作用机制,为降低肿瘤增殖、侵袭和迁移提供了新视角.
SHC1(SHC adaptor protein 1)plays a key role in tumor biology.By activating the Mitogen-Activated Protein Ki-nase/Extracellular Signal-Regulated Kinase(MAPK/ERK)and Phosphoinositide 3-Kinase-Protein Kinase B(PI3K/AKT/mTOR)signaling pathways,it regulates the proliferation,migration and invasion of tumor cells.Induce epithelial-mesenchymal transition,regulate the cytoskeleton,affect the tumor microenvironment,and thereby promote tumor invasion and migration.This article reviews the mechanism of SHC1 in various tumors,including its regulation of signaling pathways,mediation of cellular pro-cesses,and influence on the tumor microenvironment.The therapeutic strategies for SHC1 and the potential of SHC1 in tumor prognosis assessment were explored,providing new ideas for precise tumor treatment and individualized medical care.This study deeply analyzed the mechanism of SHC1 in tumor proliferation,migration and invasion,providing a new perspective for reducing tumor proliferation,invasion and migration.
郑泽洲;程端仪;孙榕;李宁;符彦淞;冯基高;赵建农
海南医科大学附属海南医院/海南省人民医院,海南 海口 570311海南医科大学附属海南医院/海南省人民医院,海南 海口 570311海南医科大学附属海南医院/海南省人民医院,海南 海口 570311海南医科大学附属海南医院/海南省人民医院,海南 海口 570311海南医科大学附属海南医院/海南省人民医院,海南 海口 570311海南医科大学第二附属医院,海南 海口 570216海南医科大学,海南 海口 571199
医药卫生
SHC1肿瘤增殖侵袭与迁移信号通路治疗靶点预后标志物
SHC1Tumor proliferationInvasion and MigrationSignal pathwayTherapeutic targetsPrognostic marker
《海南医科大学学报》 2026 (10)
785-793,9
This study was supported by the Natural Science Foundation of Hainan Province(823RC593) 海南省自然科学基金(823RC593)
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