基于"督脉通阳"探讨针灸治疗脊髓损伤的小胶质细胞调控机制OA

Spinal cord injury(SCI)is a major traumatic disease characterized by neurological dysfunction.The traditional Chinese medicine theory of"Governor vessel-mediated yang activation"provides a unique perspective for its treatment.This study innovatively constructs a theoretical model of"Governor vessel-mediated yang activation",proposing that acupuncture-moxibustion therapy improves SCI by regulating microglial M1/M2 phenotype transformation.It further analyzes the advantages of the bidirectional regulatory effect of acupuncture-moxibustion therapy and the differences in efficacy among various acupuncture-moxibustion therapy modalities.The findings elucidate that acupuncture-moxibustion therapy can effectively inhibit pro-inflammatory M1 polarization,promote reparative M2 polarization,reshape the neuroinflammatory microenvironment,and break the vicious cycle of"pro-inflammation-injury-repair inhibition",thereby providing new theoretical support for the treatment of SCI with acupuncture-moxibustion therapy.